PSMA Positive‑Negative 2‑in‑1 FFPE Paraffin Block Standard

Introduction

Prostate‑specific membrane antigen (PSMA), also known as folate hydrolase 1 (FOLH1), is a transmembrane glycoprotein consisting of extracellular C‑terminal domain, transmembrane segment and cytoplasmic N‑terminus. The extracellular region accounts for 95 % of total protein mass and serves as the primary recognition site for peptides, aptamers, small‑molecule compounds and antibodies.

PSMA is overexpressed on the cell surface in over 90 % of prostate cancer cases, with even higher expression in advanced and castration‑resistant prostate cancer (CRPC). Its expression level rises along with tumour malignancy, while normal tissues including small intestine and native prostate exhibit low‑level expression. In other solid tumours, PSMA is predominantly detected on tumour vasculature rather than tumour parenchymal cells. Therefore PSMA acts both as a tumour‑cell‑targeted biomarker for prostate cancer and an anti‑angiogenic target for other malignancies.

CBPN0081 PSMA Positive‑Negative 2‑in‑1 Paraffin Block Standard is formalin‑fixed paraffin‑embedded (FFPE) reference material designed for PSMA immunohistochemistry (IHC) assay validation and routine quality control. One single paraffin block contains both PSMA‑positive and PSMA‑negative cell populations, enabling simultaneous positive‑ and negative‑control evaluation under identical IHC experimental conditions.

Product Features

1.Positive‑negative 2‑in‑one integrated design: Both PSMA‑positive and negative components are embedded within one paraffin block, eliminating inter‑slide experimental variation.

2.FFPE paraffin format: Fully consistent with clinical pathological FFPE specimen processing workflows.

3.Well‑defined PSMA expression: Positive fraction shows robust specific membrane staining; negative fraction presents clean background without non‑specific signal.

4.Complete morphological integrity: Cell morphology remains intact for pathologist visual interpretation.

5.Pre‑validated IHC performance: Verified by PSMA‑specific IHC staining with reference antibody batch.

Product Advantages

1.Minimise deviation: Positive and negative controls go through identical antigen‑retrieval, antibody incubation and chromogenic steps, improving result comparability.

2.Cost‑efficient: Single block replaces separate positive‑control block and negative‑control block, reducing consumption and storage workload.

3.Stable long‑term storage: Paraffin block format supports long‑term preservation at‑25~‑15 ℃ with 36‑month validity.

4.Easy sectioning: Standard 4 mm block compatible with routine microtome sectioning in pathology labs.

5.Traceable QC documentation: Comes with full IHC validation records to support method‑development documentation.

Primary Applications

Routine daily quality‑control monitoring for PSMA IHC staining

PSMA IHC method establishment, optimisation and performance verification

Antibody batch qualification, antibody titre assessment and reagent screening

False‑positive / background‑noise evaluation for PSMA IHC assays

Technologist training, proficiency testing and laboratory internal assessment

Why Choose Us

1.Optimised dual‑component embedding: Mature embedding technology guarantees homogeneous distribution of positive and negative cell populations inside the paraffin block across serial sections.

2.Rigorous IHC validation: Every production batch undergoes full IHC validation using reference anti‑PSMA antibody to confirm staining performance.

3.Matching real‑world clinical workflow: FFPE format simulates actual patient pathological samples for highly relevant QC results.

4.Complete supporting documentation: Supply technical datasheets, IHC staining images and batch‑specific validation reports for your laboratory records.

5.Ready‑to‑ship inventory: Stable stock for quick delivery to support your assay‑development timeline.

Frequently Asked Questions (FAQ)

What is CBPN0081 PSMA paraffin block standard used for?

CBPN0081 is a PSMA positive‑negative 2‑in‑1 FFPE reference material for PSMA IHC method validation, antibody evaluation and daily routine quality‑control in prostate‑cancer biomarker research.

What are the storage condition and shelf‑life for CBPN0081?

Store at ‑25 ℃ ~ ‑15 ℃. The shelf‑life is 36 months from the manufacturing date.

What are the benefits of positive‑negative 2‑in‑one design?

Positive and negative samples are processed under exactly identical experimental conditions, removing inter‑slide variation and delivering more reliable background and specificity assessment compared with separate controls.

Can CBPN0081 be used for clinical diagnostic testing?

No. This product is for Research Use Only, not intended for clinical diagnostic procedures.

Is the paraffin block compatible with standard pathology‑lab section workflows?

Yes. The 4 mm‑thick paraffin block fits conventional microtome equipment for routine FFPE sectioning.