Fusion Reference Standard

Background & Product Introduction

Fusion genes, formed by chromosomal rearrangements, have become critical biomarkers for cancer diagnosis and targeted therapy selection. Over 300 clinically significant gene fusions (e.g., ALK, ROS1, NTRK) are documented in NCCN guidelines for solid tumors and hematologic malignancies.

Our fusion gene reference standards provide validated controls for NGS-based assays, containing pre-defined fusion variants at clinically relevant allele frequencies (1%-20%). These standards are designed to serve as positive controls and calibrators in molecular diagnostic assays, including qPCR, digital PCR, and next-generation sequencing (NGS).  

Key Features

• Cell-line–derived reference materials that closely mimic patient samples

• Quantitative concentration: Each batch of fusion gene standards undergoes precise quantification via digital PCR technology, providing accurate concentration references for your experiments.

• Diverse variant profiles: Offers a wide selection of fusion gene variants covering the most common fusions across various cancers (e.g., BCR-ABL1, EML4-ALK, TMPRSS2-ERG) and rare novel fusions.

• Stability and Long-Term Storage: The reference material formulation ensures long-term stability, maintaining consistent performance even after multiple freeze-thaw cycles.

• Customization Services: We understand your research may require specific fusion gene sequences. Our team stands ready to provide customized solutions tailored to your unique needs.

Applications

• Accelerate the optimization and validation of new test procedures and kits.

•  Precisely determine the sensitivity, specificity, and accuracy of your detection assays.

• Conduct robust performance comparisons across different instruments and platforms.