Fusion Reference Standard

Background & Product Introduction

Fusion genes, formed by chromosomal rearrangements, have become critical biomarkers for cancer diagnosis and targeted therapy selection. Over 300 clinically significant gene fusions (e.g., ALK, ROS1, NTRK) are documented in NCCN guidelines for solid tumors and hematologic malignancies.

Our fusion gene reference standards provide validated controls for NGS-based assays, containing pre-defined fusion variants at clinically relevant allele frequencies (1%-20%). These standards are designed to serve as positive controls and calibrators in molecular diagnostic assays, including qPCR, digital PCR, and next-generation sequencing (NGS).  

Key Features

• Cell-derived controls that closely mimic patient samples

• Quantified Concentration: Each lot of Fusion Gene Standards is precisely quantified using digital PCR, providing an accurate concentration reference for your experiments.

• Wide Range of Variants: We offer a diverse selection of fusion gene variants, covering the most common fusions observed in various cancers, such as BCR-ABL1, EML4-ALK, and TMPRSS2-ERG, as well as rare and novel fusions.

• Stability and Long Shelf Life: The standards are formulated to maintain stability over an extended period, even after multiple freeze-thaw cycles, ensuring consistent performance.

• Customization: We understand that your research may require specific fusion gene sequences. Our team is ready to provide custom services to meet your unique needs.

Applications

• Corresponding molecular detection experimental quality control products

• Optimize and verify new experimental processes or kits

•  Detection of the sensitivity, accuracy and specificity of experimental methods

• Compare the detection differences of various platforms