ATP7B Reference Standards for Multi-Platform Wilson Disease Assay Validation
For laboratories developing and validating genetic tests for Wilson disease (WD), selecting appropriate ATP7B reference standards is an important part of establishing a controlled and reproducible assay. Wilson disease testing may use Sanger sequencing, quantitative real-time PCR (qPCR), droplet digital PCR (ddPCR), or targeted next-generation sequencing (NGS). Each workflow requires well-characterized genomic DNA reference materials to evaluate analytical performance, monitor run-to-run consistency, and support reliable ATP7B variant detection and genotyping. Suitable ATP7B reference standards should have clearly defined genotypes and variant identities, a relevant sample matrix, compatibility with the intended method, and characteristics aligned with the laboratory's validation plan. This article reviews the principal considerations when selecting ATP7B reference standards for multi-platform Wilson disease assay validation.
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PSMA IHC Control Standards for IHC Assay Development and Quality Control
PSMA IHC control standards are critical reference materials for prostate cancer pathological diagnosis and targeted therapy testing. Featuring positive/negative 2‑in‑1 FFPE tissue design, they support simultaneous positive control, negative control, background evaluation, and staining specificity verification. Suitable for assay development, inter‑batch reproducibility monitoring, routine QC, and external quality assessment.
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How to Choose MSI Reference Standards for PCR-CE and NGS Assay Validation
For laboratories developing or validating microsatellite instability testing, choosing the right MSI reference standard is a critical step. MSI testing is not only about detecting instability.
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