HRR Reference Standard

Background & Product Introduction

Homologous Recombination Repair (HRR) governs a critical DNA damage repair pathway, with deficiencies strongly linked to cancer progression and therapy resistance. HRR Reference Standards are meticulously designed controls for detecting HRR gene mutations (e.g., BRCA1,BRCA2, PALB2,CHEK2), empowering researchers and clinicians to validate test accuracy in next-generation sequencing (NGS) workflows. These standards simulate precise variant allele frequencies (VAFs) mirroring real clinical samples.

Key Features

• Cell line source: closer to clinical samples

• Rigorously Verified

• Full validation through 1000x WES ,3500x panel,and ddPCR to ensures variant specificity and reproducibility.

• Comprehensive Coverage

• Covers most genes in the HRR pathway: >28 HRR-related genes, >250 mutation sites

• Customizable Pathogenic, Likely Pathogenic, VUS, Likely Benign, Benign mutation sites with multiple clinical significance

• Multi-Platform Compatibility

• Optimized for Illumina, Ion Torrent, and third-generation sequencing platforms with VAFs from 0% to 100%.

• Long-Term Stability

• gDNA format guarantees 36-month integrity at 2-8°C with controlled QC documentation.

Applications

• Biomarker discovery for HRR-deficient cancers (e.g., ovarian, prostate, pancreatic)

• PARP inhibitor efficacy prediction in clinical trials

• HRR test kit company reference

• HRR test kit internal positive and negative reference

• HRR test kit parallel comparison

• HRR test daily quality control products

• HRR test inter-laboratory quality assessment