CNV Reference Standard

Background

Copy number variation (CNV), defined as genomic structural changes involving DNA segments ≥1kb, plays a critical role in genetic disease research, cancer biomarker discovery, and precision medicine. However, the lack of universally accepted reference materials has led to inconsistent CNV detection results across different platforms and laboratories. Our CNV reference standards address this challenge by providing traceable, multiplatform-validated genomic controls.

Detection of CNV copy number variation

Currently, CNV detection technologies include fluorescence in situ hybridization (FISH), fluorescence quantitative polymerase chain reaction (PCR), multiple ligation probe amplification (MLPA), single nucleotide polymorphism gene chip (SNP array) and next-generation sequencing (NGS).

Reference products are essential in monitoring the detection process. CB-Gene has launched dozens of CNV copy number variation standards for related tumor genes.

Key Features

• Sourced from natural tumor cell lines, simulating patient samples.

• Products in different forms can be provided, such as gDNA FFPE.

• The copy number is verified by ddPCR, and the number of genes is accurately quantified.

• The product covers a wide range, including a variety of proto-oncogenes and tumor suppressor genes.