MMR Reference Standard

Background

Mismatch repair (MMR) refers to a repair method that restores the normal nucleotide sequence in a DNA molecule containing mismatched bases. It is mainly used to correct mismatched base pairs on the DNA double helix. MMR can involve multiple mismatch repair proteins when participating in DNA repair, including two major families, MutS (MSH2, MSH, and MSH6, etc.) and MutL (MLH1, MLH3, PMS1, and PMS2). Among them, MLH1, MSH2, MSH6, and PMS2 are the dominant proteins of MMR.

Product Introduction

Our MMR reference standards feature stable cell line-derived DNA.The materials undergo rigorous characterization using Sanger sequencing methods for accuracy.

Each batch is supplied with complete variant annotation files and performance data across mainstream MMR testing platforms. With expiration dating stability up to 3 years at 2-8°C, these standards provide reliable long-term quality control solutions for laboratories implementing MMR testing services.

CB-Gene has launched MMR standards for accurate calibration, which can be used for performance verification of pan-tumor MMR detection.

Key Features

• Complete process: preparation of cell line raw materials, advanced technology, rich experience

• High coverage: covering multiple cancer-related genes

• Accurate calibration: good stability and uniformity

• Verification requirements: suitable for MRR performance verification

• High efficiency: save customer procurement cycle and save customer experimental time

• Stable quality: strict QC quality inspection, stable and reliable quality

Applications

• Clinical Diagnostics: Validate MSI detection protocols for colorectal/endometrial cancer

• Research Use: Facilitate MMR gene functional studies (MLH1, MSH2, MSH6, PMS2)

• Pharma Development: Support PD-1/PD-L1 immunotherapy companion diagnostic R&D