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Lentivirus Integration Standard
Description
In 2021, my country issued four consecutive guidelines for gene therapy-related products, all of which pointed out that lentiviral integration detection should at least include 1. Integration direction 2. Integration position 3. Absolute number of clones at specific integration position and integration direction.。
In response to this requirement, CB-Gene now launches lentiviral integration site standards.
The lentiviral insertion site was determined based on the NGS (capture probe sequencing) results, and was re-verified by Sanger sequencing and ddPCR to accurately locate the lentiviral insertion site and integration frequency.
Introduction
| Monoclonal multiple insertion sites This product has been double-validated by NGS (capture method) and Sanger sequencing, indicating that it is suitable as a qualitative reference reagent for LV integration site analysis. This product can reliably detect the following 6 sites with an integration frequency of 50% More> | Monoclonal single insertion site This product has been double-validated by NGS (capture method) and Sanger sequencing, indicating that it is suitable as a qualitative reference reagent for LV integration site analysis. This product can reliably detect the following 1 site. More> | |
Multiclonal multiple integration sites This product covers 20 insertion sites, which come from 20 genes on 11 different chromosomes. Currently, there are 2 products with integration frequencies of 2% and 5% respectively. More> | Chromosome insertion site This product has been double-validated by NGS (capture method) and Sanger sequencing, indicating that it is suitable as a qualitative reference reagent for LV integration site analysis. This product can reliably detect the following 6 sites, including one sex chromosome site. More> |
