Translocation Reference Standard

Background

Translocation refers to the transfer of genetic sequences within or between chromosomes.It serves as a key biomarker for diagnosing hematologic malignancies, genetic disorders, and infertility.

To ensure accuracy and reproducibility in clinical testing and research, our translocation reference materials are meticulously designed to mimic common pathological breakpoints (e.g., ABL1-BCR, FGFR2-BICC1), providing reliable quality control for fluorescence in situ hybridization (FISH), PCR, and next-generation sequencing (NGS) platforms.

Key Features

• High Specificity & Precision :Validated genomic sequences covering breakpoint regions with ±1% accuracy, ensuring minimal cross-reactivity.

• Multi-Platform Compatibility :Optimized for FISH probes, qPCR assays, and NGS workflows, enabling seamless integration into existing diagnostic pipelines.

• Comprehensive QC Metrics :Batch-to-batch consistency verified by dual Sanger sequencing and digital droplet PCR (ddPCR).

Applications

• Clinical Oncology: Assessing the sensitivity, specificity, and stability of fusion gene detection to support the development of clinical diagnostic kits.

• Research Areas: Investigating mechanisms of chromosomal instability or validating novel translocation detection methods.