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ISA (integration site analysis)

Lenti-ISA

Lentiviral Integration Site Analysis utilizes a series of advanced molecular biology and bioinformatics techniques to sequence and analyze the genomes of cells successfully transduced with a lentiviral vector, thereby precisely identifying the specific location (i.e., the "integration site") where the viral vector DNA has inserted into the host genome.

AAV-ISA

AAV Integration Site Analysis is a technical service that utilizes high-throughput sequencing (NGS) and bioinformatics analysis to comprehensively and accurately identify the insertion location and frequency of the AAV vector genome within the host cell chromosome, as well as its surrounding genomic context. Its core purpose is to assess the integration potential and potential genotoxicity risks of AAV vectors in gene therapy products, providing critical safety data for preclinical and clinical trials.
 

Exogenous Gene-ISA

Exogenous gene Integration Site Analysis uses molecular biology techniques to precisely identify the insertion location, copy number, and integration status of an exogenous gene within the host cell genome. This test not only examines whether the exogenous gene has successfully integrated, but also focuses on analyzing the characteristics of the integration site, such as whether it is located in the gene coding region, regulatory region, or repetitive sequence, thereby assessing its potential impact on host gene function.
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Lentivirus Integration Standard
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