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Warfarin CYP2C9 Gene Polymorphism Standard

Warfarin is a widely used coumarin oral anticoagulant, which is mainly used for the prevention and treatment of thromboembolic diseases, as well as postoperative rehabilitation after bone and joint replacement, cerebral infarction and cardiac stent surgery.

Model:
CBPA0011/12/13/14/42/111/113/130
Catalog No.:
CBPA0011/12/13/14/42/111/113/130

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Description

Recent studies have found that genetic factors are the main reason for individual differences in warfarin dosage. The VKORC1 gene polymorphism related to the mechanism of action of warfarin and the CYP2C9 gene related to warfarin metabolism are closely related to its anticoagulant efficacy. Common variants that reduce the metabolic rate of warfarin are CYP2C9*2 and CYP2C9*3. In vivo and in vitro studies have shown that CYP2C9*2 and CYP2C9*3 impair the metabolism of S-warfarin by about 30-40% and about 80-90%, respectively.

The mutation of the gene site (-1639G>A) on the VKORC1 promoter is also closely related to the dose of warfarin.

General information

Cat.No.	Name	Format	Unit Size	Intended Use	Sanger sequencing	Storage	Expiry
CBPA0113	CYP2C9*1 Reference Standard	Genomic DNA	1ug	Research Use Only	CYP2C91 Reference Standard p.D397A CYP2C91 Reference Standard p.I359L CYP2C91 Reference Standard p.R144C	2~8℃	36 months
CBPA0011	CYP2C9*2 Reference Standard	Genomic DNA	1ug	Research Use Only	CBPA0011	2~8℃	36 months
CBPA0042	CYP2C9*2 Reference Standard	Genomic DNA	1ug	Research Use Only	CBPA0042	2~8℃	36 months
CBPA00130	CYP2C9*3 WT Reference Standard	Genomic DNA	1ug	Research Use Only	CBPA0130	2~8℃	36 months
CBPA0012	CYP2C9*3 Reference Standard	Genomic DNA	1ug	Research Use Only	CBPA0012	2~8℃	36 months
CBPA0013	VKORC1 -1639G>A Reference Standard	Genomic DNA	1ug	Research Use Only	CBPA0013	2~8℃	36 months
CBPA0014	VKORC1 -1639G>A Reference Standard	Genomic DNA	1ug	Research Use Only	CBPA0014	2~8℃	36 months
CBPA0111	VKORC1 rs9923231 ONLY*GG Reference Standard	Genomic DNA	1ug	Research Use Only	CBPA0111	2~8℃	36 months

Technical Data

Cat.No.	Name	Gene	AA Change	DNA Change	Zygosity	Allelic Frequency	Chr position(GRCh38)
CBPA0113	CYP2C9*1 Reference Standard	Mutation 1: CYP2C92 WT Mutation 2: CYP2C93/18 WT Mutation 3: CYP2C9*18 WT	Mutation 1: p.R144C Mutation 2: p.I359L Mutation 3: p.D397A	Mutation 1: NM_000771.4:c.430C>T Mutation 2: NM_000771.4:c.1075A>C Mutation 3: NM_000771.4:c.1190A>C	Wlid Type	0%	Mutation 1: chr10:94942290 Mutation 2: chr10:94981296 Mutation 3: chr10:94986073
CBPA0011	CYP2C9*2 Reference Standard	CYP2C9	p.R144C	NM_000771.4:c.430C>T	Heterozygous	50%	chr10:94942290
CBPA0042	CYP2C9*2 Reference Standard	CYP2C9*2	p.R144C	NM_000771.4:c.430C>T	Homozygous	100%	chr10:94942290
CBPA00130	CYP2C9*3 WT Reference Standard	CYP2C9	p.I359L	NM_000771.4:c.1075A>C	Wild type	0%	chr10:94981296A>C
CBPA0012	CYP2C9*3 Reference Standard	CYP2C9	p.I359L	NM_000771.4:c.1075A>C	Heterozygous	50%	chr10:94981296
CBPA0013	VKORC1 -1639G>A Reference Standard	VKORC1	N/A	NM_001311311.2 c.-1639 G>A	Homozygous	100%	chr16:31096368G>A
CBPA0014	VKORC1 -1639G>A Reference Standard	VKORC1	N/A	NM_001311311.2 c.-1639 G>A	Heterozygous	50%	chr16:31096368G>A
CBPA0111	VKORC1 rs9923231 ONLY*GG Reference Standard	VKORC1 rs9923231 ONLY*AA WT	N/A	NM_001311311.2 c.-1639 G>A	Wild Type	0%	chr16:31096368G>A

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