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CBPE0320-0326
CBPE0320-0326
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Product Description
SEPTIN9 gene methylation detection is playing an increasingly important role in the early screening, diagnosis and prognosis assessment of tumors, and SEPTIN9 methylation standards are key tools to ensure the accuracy and reliability of the test results.
Cancer type | Relationship with genes | Clinical application value |
Colorectal Cancer | Hypermethylation of the SEPTIN9 gene promoter region (such as the V2 transcript) causes the loss of its tumor suppressor function, which is an important event in the occurrence and development of colorectal cancer. | Blood testing for mSEPT9 is used for the diagnosis, treatment efficacy assessment, and recurrence monitoring of colorectal cancer, with a sensitivity of approximately 60% for early-stage (stage I) colorectal cancer. |
Gastric Cancer | MSEPT9 is characteristically elevated in cancer tissues of gastric cancer patients. | Plasma mSEPT9 detection has 100% specificity for the diagnosis of gastric cancer and can provide information on tumor severity and treatment response. |
Cervical Cancer | SEPTIN9 expression is significantly higher in cervical squamous cell carcinoma tissue than in normal tissue, and its expression is associated with invasive and metastatic features such as lymph node metastasis and vascular thrombus formation. | It may be involved in the invasion and metastasis of cervical cancer, but its value as an independent prognostic marker requires further study. |
Other Cancers | The SEPTIN9 gene and its methylation are associated with the development and progression of various malignancies, including breast cancer, hematologic malignancies, head and neck squamous cell carcinoma, lung cancer, and ovarian cancer. | As a potential tumor biomarker, its application in various cancers is still under investigation. |
The SEPTIN9 protein, encoded by the SEPTIN9 gene, is involved in cytoskeletal functions and various physiological processes, including cell division and morphological maintenance. Hypermethylation of the gene's promoter region leads to transcriptional silencing, abolishing its tumor suppressor function and promoting tumor development and progression. In addition to the cancers listed in the table, SEPTIN9 gene methylation has also been associated with a variety of malignancies, including breast, lung, and ovarian cancer, demonstrating its potential as a broad-spectrum tumor marker.
A SEPTIN9 methylation standard is a reference material used for quality control and standardization. It is typically derived from genomic DNA (gDNA) extracted from a specific cell line in which the methylation level of a specific region of the SEPTIN9 gene (such as the promoter) is known and stable (e.g., 90% or 95%).
When developing and validating SEPTIN9 methylation detection methods (e.g., PCR, sequencing, etc.), standards can be used to assess the accuracy, sensitivity, and specificity of the detection method. They can also serve as positive controls to ensure the validity of each detection experiment and the reliability of the results. They can help quantitatively or semi-quantitatively determine the methylation level of SEPTIN9 in the sample being tested.
General information
Name | Septin9 methylation single gene single segment standard |
Cat. No. | CBPE0320-0326 |
Format | Genomic DNA |
Size | 1ug |
Buffer | Tris-EDTA |
Intended Use | Research Use Only |
Concentration | Download for COA |
Purity | Download for COA |
DNA electrophoresis | Download for COA |
Storage Conditions | 2~8℃ |
Expiry | 36 months from the date of manufacture |
Remark | The data in the instruction manual is the data of a single test, and the specific data of each batch is subject to delivery. |
Technical Data
Classification | Cat No. | Name | Unit Size | Methylation level | |
Chr17:75369001-75369079(hg19) | |||||
quality control standard | Positive quality control | CBPE0320 | Septin9 Methylation Positive control | 1ug | 94.48% |
Negative quality control | CBPE0321 | Septin9 Methylation Negative control (< Cut off) | 1ug | 0.03% | |
Reference Standard | High positive reference-1 | CBPE0322 | Septin9 Methylation Reference Standard with > 90% | 1ug | 94.48% |
High positive reference-2 | CBPE0323 | Septin9 Methylation Reference Standard with 10% | 1ug | N/A | |
Low positive reference | CBPE0324 | Septin9 Methylation Reference Standard with 3% | 1ug | N/A | |
LOD reference | CBPE0325 | Septin9 Methylation Reference Standard with 1% | 1ug | 1.14% | |
Negative reference | CBPE0326 | Septin9 Methylation Negative Reference Standard (< Cut off) | 1ug | 0.03% | |
Precision reference | CBPE0324 | Septin9 Methylation Reference Standard with 3% | 1ug | N/A | |
CBPE0326 | Septin9 Methylation Negative Reference Standard (< Cut off) | 1ug | 0.03% | ||
Specificity reference | Customization | ||||
Remark | 1. Quality control products are also called accuracy standards, which are used for qualitative judgment; 2. Reference products are used for qualitative and quantitative judgments, among which the judgment of strong positive, weak positive, detection limit, precision, and specificity depends on the specific project. The judgment of this product is only an internal standard; 3. Quality control products are used for performance evaluation, factory inspection, and routine testing and judgment of test kits, and reference products are used for performance evaluation and factory inspection; | ||||
Product Description
SEPTIN9 gene methylation detection is playing an increasingly important role in the early screening, diagnosis and prognosis assessment of tumors, and SEPTIN9 methylation standards are key tools to ensure the accuracy and reliability of the test results.
Cancer type | Relationship with genes | Clinical application value |
Colorectal Cancer | Hypermethylation of the SEPTIN9 gene promoter region (such as the V2 transcript) causes the loss of its tumor suppressor function, which is an important event in the occurrence and development of colorectal cancer. | Blood testing for mSEPT9 is used for the diagnosis, treatment efficacy assessment, and recurrence monitoring of colorectal cancer, with a sensitivity of approximately 60% for early-stage (stage I) colorectal cancer. |
Gastric Cancer | MSEPT9 is characteristically elevated in cancer tissues of gastric cancer patients. | Plasma mSEPT9 detection has 100% specificity for the diagnosis of gastric cancer and can provide information on tumor severity and treatment response. |
Cervical Cancer | SEPTIN9 expression is significantly higher in cervical squamous cell carcinoma tissue than in normal tissue, and its expression is associated with invasive and metastatic features such as lymph node metastasis and vascular thrombus formation. | It may be involved in the invasion and metastasis of cervical cancer, but its value as an independent prognostic marker requires further study. |
Other Cancers | The SEPTIN9 gene and its methylation are associated with the development and progression of various malignancies, including breast cancer, hematologic malignancies, head and neck squamous cell carcinoma, lung cancer, and ovarian cancer. | As a potential tumor biomarker, its application in various cancers is still under investigation. |
The SEPTIN9 protein, encoded by the SEPTIN9 gene, is involved in cytoskeletal functions and various physiological processes, including cell division and morphological maintenance. Hypermethylation of the gene's promoter region leads to transcriptional silencing, abolishing its tumor suppressor function and promoting tumor development and progression. In addition to the cancers listed in the table, SEPTIN9 gene methylation has also been associated with a variety of malignancies, including breast, lung, and ovarian cancer, demonstrating its potential as a broad-spectrum tumor marker.
A SEPTIN9 methylation standard is a reference material used for quality control and standardization. It is typically derived from genomic DNA (gDNA) extracted from a specific cell line in which the methylation level of a specific region of the SEPTIN9 gene (such as the promoter) is known and stable (e.g., 90% or 95%).
When developing and validating SEPTIN9 methylation detection methods (e.g., PCR, sequencing, etc.), standards can be used to assess the accuracy, sensitivity, and specificity of the detection method. They can also serve as positive controls to ensure the validity of each detection experiment and the reliability of the results. They can help quantitatively or semi-quantitatively determine the methylation level of SEPTIN9 in the sample being tested.
General information
Name | Septin9 methylation single gene single segment standard |
Cat. No. | CBPE0320-0326 |
Format | Genomic DNA |
Size | 1ug |
Buffer | Tris-EDTA |
Intended Use | Research Use Only |
Concentration | Download for COA |
Purity | Download for COA |
DNA electrophoresis | Download for COA |
Storage Conditions | 2~8℃ |
Expiry | 36 months from the date of manufacture |
Remark | The data in the instruction manual is the data of a single test, and the specific data of each batch is subject to delivery. |
Technical Data
Classification | Cat No. | Name | Unit Size | Methylation level | |
Chr17:75369001-75369079(hg19) | |||||
quality control standard | Positive quality control | CBPE0320 | Septin9 Methylation Positive control | 1ug | 94.48% |
Negative quality control | CBPE0321 | Septin9 Methylation Negative control (< Cut off) | 1ug | 0.03% | |
Reference Standard | High positive reference-1 | CBPE0322 | Septin9 Methylation Reference Standard with > 90% | 1ug | 94.48% |
High positive reference-2 | CBPE0323 | Septin9 Methylation Reference Standard with 10% | 1ug | N/A | |
Low positive reference | CBPE0324 | Septin9 Methylation Reference Standard with 3% | 1ug | N/A | |
LOD reference | CBPE0325 | Septin9 Methylation Reference Standard with 1% | 1ug | 1.14% | |
Negative reference | CBPE0326 | Septin9 Methylation Negative Reference Standard (< Cut off) | 1ug | 0.03% | |
Precision reference | CBPE0324 | Septin9 Methylation Reference Standard with 3% | 1ug | N/A | |
CBPE0326 | Septin9 Methylation Negative Reference Standard (< Cut off) | 1ug | 0.03% | ||
Specificity reference | Customization | ||||
Remark | 1. Quality control products are also called accuracy standards, which are used for qualitative judgment; 2. Reference products are used for qualitative and quantitative judgments, among which the judgment of strong positive, weak positive, detection limit, precision, and specificity depends on the specific project. The judgment of this product is only an internal standard; 3. Quality control products are used for performance evaluation, factory inspection, and routine testing and judgment of test kits, and reference products are used for performance evaluation and factory inspection; | ||||
General information
Name | Septin9 methylation single gene single segment standard |
Cat. No. | CBPE0320-0326 |
Format | Genomic DNA |
Size | 1ug |
Buffer | Tris-EDTA |
Intended Use | Research Use Only |
Concentration | Download for COA |
Purity | Download for COA |
DNA electrophoresis | Download for COA |
Storage Conditions | 2~8℃ |
Expiry | 36 months from the date of manufacture |
Remark | The data in the instruction manual is the data of a single test, and the specific data of each batch is subject to delivery. |
General information
Name | Septin9 methylation single gene single segment standard |
Cat. No. | CBPE0320-0326 |
Format | Genomic DNA |
Size | 1ug |
Buffer | Tris-EDTA |
Intended Use | Research Use Only |
Concentration | Download for COA |
Purity | Download for COA |
DNA electrophoresis | Download for COA |
Storage Conditions | 2~8℃ |
Expiry | 36 months from the date of manufacture |
Remark | The data in the instruction manual is the data of a single test, and the specific data of each batch is subject to delivery. |
Technical Data
Classification | Cat No. | Name | Unit Size | Methylation level | |
Chr17:75369001-75369079(hg19) | |||||
quality control standard | Positive quality control | CBPE0320 | Septin9 Methylation Positive control | 1ug | 94.48% |
Negative quality control | CBPE0321 | Septin9 Methylation Negative control (< Cut off) | 1ug | 0.03% | |
Reference Standard | High positive reference-1 | CBPE0322 | Septin9 Methylation Reference Standard with > 90% | 1ug | 94.48% |
High positive reference-2 | CBPE0323 | Septin9 Methylation Reference Standard with 10% | 1ug | N/A | |
Low positive reference | CBPE0324 | Septin9 Methylation Reference Standard with 3% | 1ug | N/A | |
LOD reference | CBPE0325 | Septin9 Methylation Reference Standard with 1% | 1ug | 1.14% | |
Negative reference | CBPE0326 | Septin9 Methylation Negative Reference Standard (< Cut off) | 1ug | 0.03% | |
Precision reference | CBPE0324 | Septin9 Methylation Reference Standard with 3% | 1ug | N/A | |
CBPE0326 | Septin9 Methylation Negative Reference Standard (< Cut off) | 1ug | 0.03% | ||
Specificity reference | Customization | ||||
Remark | 1. Quality control products are also called accuracy standards, which are used for qualitative judgment; 2. Reference products are used for qualitative and quantitative judgments, among which the judgment of strong positive, weak positive, detection limit, precision, and specificity depends on the specific project. The judgment of this product is only an internal standard; 3. Quality control products are used for performance evaluation, factory inspection, and routine testing and judgment of test kits, and reference products are used for performance evaluation and factory inspection; | ||||
Technical Data
Classification | Cat No. | Name | Unit Size | Methylation level | |
Chr17:75369001-75369079(hg19) | |||||
quality control standard | Positive quality control | CBPE0320 | Septin9 Methylation Positive control | 1ug | 94.48% |
Negative quality control | CBPE0321 | Septin9 Methylation Negative control (< Cut off) | 1ug | 0.03% | |
Reference Standard | High positive reference-1 | CBPE0322 | Septin9 Methylation Reference Standard with > 90% | 1ug | 94.48% |
High positive reference-2 | CBPE0323 | Septin9 Methylation Reference Standard with 10% | 1ug | N/A | |
Low positive reference | CBPE0324 | Septin9 Methylation Reference Standard with 3% | 1ug | N/A | |
LOD reference | CBPE0325 | Septin9 Methylation Reference Standard with 1% | 1ug | 1.14% | |
Negative reference | CBPE0326 | Septin9 Methylation Negative Reference Standard (< Cut off) | 1ug | 0.03% | |
Precision reference | CBPE0324 | Septin9 Methylation Reference Standard with 3% | 1ug | N/A | |
CBPE0326 | Septin9 Methylation Negative Reference Standard (< Cut off) | 1ug | 0.03% | ||
Specificity reference | Customization | ||||
Remark | 1. Quality control products are also called accuracy standards, which are used for qualitative judgment; 2. Reference products are used for qualitative and quantitative judgments, among which the judgment of strong positive, weak positive, detection limit, precision, and specificity depends on the specific project. The judgment of this product is only an internal standard; 3. Quality control products are used for performance evaluation, factory inspection, and routine testing and judgment of test kits, and reference products are used for performance evaluation and factory inspection; | ||||
