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Package-Ref™ Liver Cancer PLAC8/BMPR1A for Methylation control

Model:
CBPE0221
Catalog No.:
CBPE0221

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Product Description

This package contains multiple detection samples for Liver Cancer, We use simulated clinical cell lines to prepare them. If you are testing PLAC8/BMPR1A, you can choose this product.

PLAC8 (placenta-specific protein 8) expression is restricted under normal physiological conditions, but it is abnormally overexpressed in various cancers. It is considered an oncogene that significantly promotes cell proliferation, migration, and invasion.

·Methylation Influence: In liver cancer, the PLAC8 gene promoter region is often hypomethylated (demethylated). Promoter hypomethylation typically relieves the repression of gene transcription, leading to gene activation and overexpression.

·Link to Liver Cancer: Abnormally high expression of PLAC8 activates multiple pro-oncogenic signaling pathways (such as the Wnt/β-catenin pathway), driving hepatocyte malignant transformation and tumor progression. Its high expression is closely associated with poor prognosis and higher recurrence rates in liver cancer patients.

BMPR1A (bone morphogenetic protein receptor 1A) is a key component of the BMP signaling pathway. In normal tissues, the BMP pathway primarily regulates cell growth, differentiation, and apoptosis, often acting as a tumor suppressor.

·Methylation Influence: In liver cancer, the promoter region of the BMPR1A gene is frequently hypermethylated. This hypermethylation acts like a "lock," preventing the transcriptional machinery from binding to the promoter, leading to gene silencing or significant downregulation of expression.

·Link to Liver Cancer: Silencing BMPR1A abolishes its tumor suppressor function. Disruption of the BMP signaling pathway deregulates cell proliferation and inhibits apoptosis, creating conditions conducive to the development and progression of liver cancer. Methylation levels are positively correlated with the malignancy of liver cancer.

PLAC8 and BMPR1A play opposing yet synergistic roles in liver cancer through epigenetic modifications (methylation):

PLAC8 demethylation leads to the activation of an oncogene.BMPR1A hypermethylation leads to the inactivation of a tumor suppressor gene.

This synergistic "on/off" effect significantly promotes liver cell carcinogenesis and tumor progression. Therefore, monitoring the methylation status of these two genes has significant potential for early diagnosis, risk prediction, and prognostic assessment of liver cancer.

General information

Name	Package-Ref™ Liver Cancer PLAC8/BMPR1A for Methylation control
Cat. No.	CBPE0221
Format	Genomic DNA
Size	1ug
Buffer	Tris-EDTA
Intended Use	Research Use Only
Concentration	Download for COA
Purity	Download for COA
DNA electrophoresis	Download for COA
Storage Conditions	2~8℃
Expiry	36 months from the date of manufacture
Remark	The data in the instruction manual is the data of a single test, and the specific data of each batch is subject to delivery.

Technical Data

Classification	Cat No.	Name		Description	Region	Methylation level
quality control standard	CBPE0221-1	Liver Cancer-PLAC8,BMPR1A Positive methylation		PLAC8 Methylation with Positive control	chr4:84035895-84035987 (hg19)	94.20%
	CBPE0221-1	Liver Cancer-PLAC8,BMPR1A Positive methylation		BMPR1A Methylation with Positive control	chr10:88683965-88684051 (hg19)	95.75%
	CBPE0221-2	Liver Cancer-PLAC8,BMPR1A Negative methylation		PLAC8 Methylation with Negative control	chr4:84035895-84035987 (hg19)	N/A
	CBPE0221-2	Liver Cancer-PLAC8,BMPR1A Negative methylation		BMPR1A Methylation with Negative control	chr10:88683965-88684051 (hg19)	N/A
	CBPE0221-3	Liver Cancer-PLAC8 Negative methylation，BMPR1A Positive methylation		PLAC8 Methylation with Negative control	chr4:84035895-84035987 (hg19)	0.00%
	CBPE0221-3			BMPR1A Methylation with Positive control	chr10:88683965-88684051 (hg19)	96.59%
	CBPE0221-4	Liver Cancer-BMPR1A Negative methylation，PLAC8 Positive methylation		PLAC8 Methylation with Positive control	chr4:84035895-84035987 (hg19)	N/A
	CBPE0221-4			BMPR1A Methylation with Negative control	chr10:88683965-88684051(hg19)	N/A

Classification		Cat No.	Name	Description	Region	Methylation level
Single positive PLAC8-reference standard	Single positive PLAC8 segment-High Positive reference-1	CBPE0221-5	PLAC8 High Positive methylation reference，BMPR1A Negative methylation	PLAC8 Methylation Reference Standard with 90.00%	chr4:84035895-84035987(hg19)	N/A
	Single positive PLAC8 segment-High Positive reference-1	CBPE0221-5		BMPR1A Methylation with Negative control	chr10:88683965-88684051(hg19)	N/A
	Single positive PLAC8 segment-High Positive reference-2	CBPE0221-6	PLAC8 High Positive methylation reference，BMPR1A Negative methylation	PLAC8 Methylation Reference Standard with 10.00%	chr4:84035895-84035987(hg19)	N/A
	Single positive PLAC8 segment-High Positive reference-2	CBPE0221-6		BMPR1A Methylation Negative Reference Standard	chr10:88683965-88684051(hg19)	N/A
	Single positive PLAC8 segment-Low Positive reference	CBPE0221-7	PLAC8 Low Positive methylation reference，BMPR1A Negative methylation	PLAC8 Methylation Reference Standard with 3.00%	chr4:84035895-84035987(hg19)	N/A
	Single positive PLAC8 segment-Low Positive reference	CBPE0221-7		BMPR1A Methylation Negative Reference Standard	chr10:88683965-88684051(hg19)	N/A
	Single positive PLAC8 segment-LOD reference	CBPE0221-8	PLAC8 LOD reference，BMPR1A Negative methylation	PLAC8 Methylation Reference Standard with 1.00%	chr4:84035895-84035987(hg19)	1.17%
	Single positive PLAC8 segment-LOD reference	CBPE0221-8	PLAC8 LOD reference，BMPR1A Negative methylation	BMPR1A Methylation Negative Reference Standard	chr10:88683965-88684051(hg19)	N/A
	Single positive PLAC8 segment-Negative methylation	CBPE0221-9	Liver Cancer-PLAC8,BMPR1A Negative methylation	PLAC8 Methylation with Negative control	chr4:84035895-84035987(hg19)	N/A
	Single positive PLAC8 segment-Negative methylation	CBPE0221-9	Liver Cancer-PLAC8,BMPR1A Negative methylation	BMPR1A Methylation with Negative control	chr10:88683965-88684051(hg19)	N/A
	Single positive PLAC8 segment-precision reference	CBPE0221-10	PLAC8 Low Positive methylation reference,BMPR1A Negative methylation	PLAC8 Methylation Reference Standard with 3.00%	chr4:84035895-84035987(hg19)	N/A
		CBPE0221-10		BMPR1A Methylation Negative Reference Standard	chr10:88683965-88684051(hg19)	N/A
		CBPE0221-11	Liver Cancer-PLAC8,BMPR1A Negative methylation	PLAC8 Methylation with Negative control	chr4:84035895-84035987(hg19)	N/A
		CBPE0221-11	Liver Cancer-PLAC8,BMPR1A Negative methylation	BMPR1A Methylation with Negative control	chr10:88683965-88684051(hg19)	N/A

Classification		Cat No.	Name	Description	Region	Methylation level
Single positiveBMPR1A-reference standard	Single positive BMPR1A segment-High Positive methylation reference-1	CBPE0221-12	BMPR1A High Positive methylation reference，PLAC8 Negative methylation	BMPR1A Methylation Reference Standard with 90.00%	chr10:88683965-88684051(hg19)	96.59%
		CBPE0221-12		PLAC8 Methylation with Negative control	chr4:84035895-84035987(hg19)	0.00%
	Single positive BMPR1A segment-High Positive methylation reference-2	CBPE0221-13	BMPR1A High Positive methylation reference，PLAC8 Negative methylation	BMPR1A Methylation Reference Standard with 10.00%	chr10:88683965-88684051(hg19)	N/A
		CBPE0221-13		PLAC8 Methylation with Negative control	chr4:84035895-84035987(hg19)	N/A
	Single positive BMPR1A segment-Low Positive methylation reference	CBPE0221-14	BMPR1A Low Positive methylation reference，PLAC8 Negative methylation	BMPR1A Methylation Reference Standard with 3.00%	chr10:88683965-88684051(hg19)	N/A
		CBPE0221-14		PLAC8 Methylation with Negative control	chr4:84035895-84035987(hg19)	N/A
	Single positive BMPR1A segment-LOD reference	CBPE0221-15	BMPR1A LOD methylation reference，PLAC8 Negative methylation	BMPR1A Methylation Reference Standard with 1.00%	chr10:88683965-88684051(hg19)	N/A
	Single positive BMPR1A segment-LOD reference	CBPE0221-15	BMPR1A LOD methylation reference，PLAC8 Negative methylation	PLAC8 Methylation with Negative control	chr4:84035895-84035987(hg19)	N/A
	Single positive BMPR1A segment-Negative reference	CBPE0221-16	Liver Cancer-PLAC8,BMPR1A Negative methylation	PLAC8 Methylation with Negative control	chr4:84035895-84035987(hg19)	N/A
	Single positive BMPR1A segment-Negative reference	CBPE0221-16	Liver Cancer-PLAC8,BMPR1A Negative methylation	BMPR1A Methylation with Negative control	chr10:88683965-88684051(hg19)	N/A
	Single positive BMPR1A segment-Precision reference	CBPE0221-17	BMPR1A Low Positive methylation reference，PLAC8 Negative methylation	BMPR1A Methylation Reference Standard with 3.00%	chr10:88683965-88684051(hg19)	N/A
		CBPE0221-17		PLAC8 Methylation with Negative control	chr4:84035895-84035987(hg19)	N/A
		CBPE0221-18	Liver Cancer-PLAC8,BMPR1A Negative methylation	PLAC8 Methylation with Negative control	chr4:84035895-84035987(hg19)	N/A
		CBPE0221-18	Liver Cancer-PLAC8,BMPR1A Negative methylation	BMPR1A Methylation with Negative control	chr10:88683965-88684051 (hg19)	N/A
Remark	1.Quality control products are also called accuracy standards and are used for qualitative judgment; 2. Reference products are used for qualitative and quantitative judgments. The judgment of strong positive, weak positive, detection limit, precision and specificity depends on the specific project. The judgment of this product is only an internal standard; 3. Quality control products are used for performance evaluation, factory inspection, and daily detection and judgment of test kits. Reference products are used for performance evaluation and factory inspection; 4. The above products only show part of the results, and the degree of methylation can be customized.

Technical Data

Classification	Cat No.	Name		Description	Region	Methylation level
quality control standard	CBPE0221-1	Liver Cancer-PLAC8,BMPR1A Positive methylation		PLAC8 Methylation with Positive control	chr4:84035895-84035987 (hg19)	94.20%
	CBPE0221-1	Liver Cancer-PLAC8,BMPR1A Positive methylation		BMPR1A Methylation with Positive control	chr10:88683965-88684051 (hg19)	95.75%
	CBPE0221-2	Liver Cancer-PLAC8,BMPR1A Negative methylation		PLAC8 Methylation with Negative control	chr4:84035895-84035987 (hg19)	N/A
	CBPE0221-2	Liver Cancer-PLAC8,BMPR1A Negative methylation		BMPR1A Methylation with Negative control	chr10:88683965-88684051 (hg19)	N/A
	CBPE0221-3	Liver Cancer-PLAC8 Negative methylation，BMPR1A Positive methylation		PLAC8 Methylation with Negative control	chr4:84035895-84035987 (hg19)	0.00%
	CBPE0221-3			BMPR1A Methylation with Positive control	chr10:88683965-88684051 (hg19)	96.59%
	CBPE0221-4	Liver Cancer-BMPR1A Negative methylation，PLAC8 Positive methylation		PLAC8 Methylation with Positive control	chr4:84035895-84035987 (hg19)	N/A
	CBPE0221-4			BMPR1A Methylation with Negative control	chr10:88683965-88684051(hg19)	N/A

Classification		Cat No.	Name	Description	Region	Methylation level
Single positive PLAC8-reference standard	Single positive PLAC8 segment-High Positive reference-1	CBPE0221-5	PLAC8 High Positive methylation reference，BMPR1A Negative methylation	PLAC8 Methylation Reference Standard with 90.00%	chr4:84035895-84035987(hg19)	N/A
	Single positive PLAC8 segment-High Positive reference-1	CBPE0221-5		BMPR1A Methylation with Negative control	chr10:88683965-88684051(hg19)	N/A
	Single positive PLAC8 segment-High Positive reference-2	CBPE0221-6	PLAC8 High Positive methylation reference，BMPR1A Negative methylation	PLAC8 Methylation Reference Standard with 10.00%	chr4:84035895-84035987(hg19)	N/A
	Single positive PLAC8 segment-High Positive reference-2	CBPE0221-6		BMPR1A Methylation Negative Reference Standard	chr10:88683965-88684051(hg19)	N/A
	Single positive PLAC8 segment-Low Positive reference	CBPE0221-7	PLAC8 Low Positive methylation reference，BMPR1A Negative methylation	PLAC8 Methylation Reference Standard with 3.00%	chr4:84035895-84035987(hg19)	N/A
	Single positive PLAC8 segment-Low Positive reference	CBPE0221-7		BMPR1A Methylation Negative Reference Standard	chr10:88683965-88684051(hg19)	N/A
	Single positive PLAC8 segment-LOD reference	CBPE0221-8	PLAC8 LOD reference，BMPR1A Negative methylation	PLAC8 Methylation Reference Standard with 1.00%	chr4:84035895-84035987(hg19)	1.17%
	Single positive PLAC8 segment-LOD reference	CBPE0221-8	PLAC8 LOD reference，BMPR1A Negative methylation	BMPR1A Methylation Negative Reference Standard	chr10:88683965-88684051(hg19)	N/A
	Single positive PLAC8 segment-Negative methylation	CBPE0221-9	Liver Cancer-PLAC8,BMPR1A Negative methylation	PLAC8 Methylation with Negative control	chr4:84035895-84035987(hg19)	N/A
	Single positive PLAC8 segment-Negative methylation	CBPE0221-9	Liver Cancer-PLAC8,BMPR1A Negative methylation	BMPR1A Methylation with Negative control	chr10:88683965-88684051(hg19)	N/A
	Single positive PLAC8 segment-precision reference	CBPE0221-10	PLAC8 Low Positive methylation reference,BMPR1A Negative methylation	PLAC8 Methylation Reference Standard with 3.00%	chr4:84035895-84035987(hg19)	N/A
		CBPE0221-10		BMPR1A Methylation Negative Reference Standard	chr10:88683965-88684051(hg19)	N/A
		CBPE0221-11	Liver Cancer-PLAC8,BMPR1A Negative methylation	PLAC8 Methylation with Negative control	chr4:84035895-84035987(hg19)	N/A
		CBPE0221-11	Liver Cancer-PLAC8,BMPR1A Negative methylation	BMPR1A Methylation with Negative control	chr10:88683965-88684051(hg19)	N/A

Classification		Cat No.	Name	Description	Region	Methylation level
Single positiveBMPR1A-reference standard	Single positive BMPR1A segment-High Positive methylation reference-1	CBPE0221-12	BMPR1A High Positive methylation reference，PLAC8 Negative methylation	BMPR1A Methylation Reference Standard with 90.00%	chr10:88683965-88684051(hg19)	96.59%
		CBPE0221-12		PLAC8 Methylation with Negative control	chr4:84035895-84035987(hg19)	0.00%
	Single positive BMPR1A segment-High Positive methylation reference-2	CBPE0221-13	BMPR1A High Positive methylation reference，PLAC8 Negative methylation	BMPR1A Methylation Reference Standard with 10.00%	chr10:88683965-88684051(hg19)	N/A
		CBPE0221-13		PLAC8 Methylation with Negative control	chr4:84035895-84035987(hg19)	N/A
	Single positive BMPR1A segment-Low Positive methylation reference	CBPE0221-14	BMPR1A Low Positive methylation reference，PLAC8 Negative methylation	BMPR1A Methylation Reference Standard with 3.00%	chr10:88683965-88684051(hg19)	N/A
		CBPE0221-14		PLAC8 Methylation with Negative control	chr4:84035895-84035987(hg19)	N/A
	Single positive BMPR1A segment-LOD reference	CBPE0221-15	BMPR1A LOD methylation reference，PLAC8 Negative methylation	BMPR1A Methylation Reference Standard with 1.00%	chr10:88683965-88684051(hg19)	N/A
	Single positive BMPR1A segment-LOD reference	CBPE0221-15	BMPR1A LOD methylation reference，PLAC8 Negative methylation	PLAC8 Methylation with Negative control	chr4:84035895-84035987(hg19)	N/A
	Single positive BMPR1A segment-Negative reference	CBPE0221-16	Liver Cancer-PLAC8,BMPR1A Negative methylation	PLAC8 Methylation with Negative control	chr4:84035895-84035987(hg19)	N/A
	Single positive BMPR1A segment-Negative reference	CBPE0221-16	Liver Cancer-PLAC8,BMPR1A Negative methylation	BMPR1A Methylation with Negative control	chr10:88683965-88684051(hg19)	N/A
	Single positive BMPR1A segment-Precision reference	CBPE0221-17	BMPR1A Low Positive methylation reference，PLAC8 Negative methylation	BMPR1A Methylation Reference Standard with 3.00%	chr10:88683965-88684051(hg19)	N/A
		CBPE0221-17		PLAC8 Methylation with Negative control	chr4:84035895-84035987(hg19)	N/A
		CBPE0221-18	Liver Cancer-PLAC8,BMPR1A Negative methylation	PLAC8 Methylation with Negative control	chr4:84035895-84035987(hg19)	N/A
		CBPE0221-18	Liver Cancer-PLAC8,BMPR1A Negative methylation	BMPR1A Methylation with Negative control	chr10:88683965-88684051 (hg19)	N/A
Remark	1.Quality control products are also called accuracy standards and are used for qualitative judgment; 2. Reference products are used for qualitative and quantitative judgments. The judgment of strong positive, weak positive, detection limit, precision and specificity depends on the specific project. The judgment of this product is only an internal standard; 3. Quality control products are used for performance evaluation, factory inspection, and daily detection and judgment of test kits. Reference products are used for performance evaluation and factory inspection; 4. The above products only show part of the results, and the degree of methylation can be customized.

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