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CBPE0412
CBPE0412
| Availability: | |
|---|---|
Product Description
In colorectal cancer (CRC), methylation of the SDC2 (Syndecan-2) and TFPI2 (Tissue Factor Pathway Inhibitor 2) genes is a common early molecular event.
Under normal circumstances, the promoter regions of these two genes are unmethylated, allowing normal gene expression. The SDC2 protein is involved in processes such as cell proliferation and adhesion, while TFPI2 is a tumor suppressor gene whose protein product inhibits tumor invasion and metastasis. Hypermethylation of the promoter regions of these genes leads to transcriptional silencing, abolishing their normal tumor suppressor function1, thereby promoting the development and progression of colorectal cancer. Therefore, monitoring the methylation status of these genes can effectively detect early signals of colorectal cancer and its precancerous lesions, such as adenomas.
This package contains multiple detection samples for Colorectal cancer, We use simulated clinical cell lines to prepare them. If you are testing SDC2/TFPI2, you can choose this product.
General information
| Name | Package-Ref™ Colorectal cancer SDC2/TFPI2 for Methylation control |
| Cat. No. | CBPE0412 |
| Format | Genomic DNA |
| Size | 1ug |
| Buffer | Tris-EDTA |
| Intended Use | Research Use Only |
| Concentration | Download for COA |
| Purity | Download for COA |
| DNA electrophoresis | Download for COA |
| Storage Conditions | 2~8℃ |
| Expiry | 36 months from the date of manufacture |
| Remark | The data in the instruction manual is the data of a single test, and the specific data of each batch is subject to delivery. |
Technical Data
| Classification | Cat No. | Name | Description | Region | Methylation level | |
| quality control standard | CBPE0412-1 | Colorectal cancer-SDC2,TFPI2 Positive methylation | SDC2 Methylation with Positive control | Chr8:97506434-97506502(hg19) | N/A | |
| TFPI2 Methylation with Positive control | Chr7:93519461-93519624(hg19) | N/A | ||||
| CBPE0412-2 | Colorectal cancer-SDC2,TFPI2 Negative methylation | SDC2 Methylation with Negative control | Chr8:97506434-97506502(hg19) | N/A | ||
| TFPI2 Methylation with Negative control | Chr7:93519461-93519624(hg19) | N/A | ||||
| CBPE0412-3 | Colorectal cancer-SDC2 Negative methylation，TFPI2 Positive methylation | SDC2 Methylation with Negative control | Chr8:97506434-97506502(hg19) | 0.19% | ||
| TFPI2 Methylation with Positive control | Chr7:93519461-93519624(hg19) | 33.09% | ||||
| CBPE0412-4 | Colorectal cancer-TFPI2 Negative methylation，SDC2 Positive methylation | SDC2 Methylation with Positive control | Chr8:97506434-97506502(hg19) | 49.09% | ||
| TFPI2 Methylation with Negative control | Chr7:93519461-93519624(hg19) | 0.08% | ||||
| Classification | Cat No. | Name | Description | Region | Methylation level | |
| Single positive SDC2-reference standard | Single positive SDC2 segment-High Positive reference-1 | CBPE0412-5 | SDC2 High Positive methylation reference，TFPI2 Negative methylation | SDC2 Methylation Reference Standard with 45.00% | Chr8:97506434-97506502(hg19) | 49.09% |
| TFPI2 Methylation with Negative control | Chr7:93519461-93519624(hg19) | 0.08% | ||||
| Single positive SDC2 segment-High Positive reference-2 | CBPE0412-6 | SDC2 High Positive methylation reference，TFPI2 Negative methylation | SDC2 Methylation Reference Standard with 10.00% | Chr8:97506434-97506502(hg19) | 9.12% | |
| TFPI2 Methylation Negative Reference Standard | Chr7:93519461-93519624(hg19) | N/A | ||||
| Single positive SDC2 segment-Low Positive reference | CBPE0412-7 | SDC2 Low Positive methylation reference，TFPI2 Negative methylation | SDC2 Methylation Reference Standard with 3.00% | Chr8:97506434-97506502(hg19) | N/A | |
| TFPI2 Methylation Negative Reference Standard | Chr7:93519461-93519624(hg19) | N/A | ||||
| Single positive SDC2 segment-LOD reference | CBPE0412-8 | SDC2 LOD reference，TFPI2 Negative methylation | SDC2 Methylation Reference Standard with 1.00% | Chr8:97506434-97506502(hg19) | 1.17% | |
| TFPI2 Methylation Negative Reference Standard | Chr7:93519461-93519624(hg19) | N/A | ||||
| Single positive SDC2 segment-Negative methylation | CBPE0412-9 | Colorectal cancer-SDC2,TFPI2 Negative methylation | SDC2 Methylation with Negative control | Chr8:97506434-97506502(hg19) | N/A | |
| TFPI2 Methylation with Negative control | Chr7:93519461-93519624(hg19) | N/A | ||||
| Single positive SDC2 segment-precision reference | CBPE0412-10 | SDC2 Low Positive methylation reference,TFPI2 Negative methylation | SDC2 Methylation Reference Standard with 3.00% | Chr8:97506434-97506502(hg19) | N/A | |
| TFPI2 Methylation Negative Reference Standard | Chr7:93519461-93519624(hg19) | N/A | ||||
| CBPE0412-11 | Colorectal cancer-SDC2,TFPI2 Negative methylation | SDC2 Methylation with Negative control | Chr8:97506434-97506502(hg19) | N/A | ||
| TFPI2 Methylation with Negative control | Chr7:93519461-93519624(hg19) | N/A | ||||
| Classification | Cat No. | Name | Description | Region | Methylation level | |
| Single positiveTFPI2-reference standard | Single positive TFPI2 segment-High Positive methylation reference-1 | CBPE0412-12 | TFPI2 High Positive methylation reference，SDC2 Negative methylation | TFPI2 Methylation Reference Standard with 30.00% | Chr7:93519461-93519624(hg19) | 33.09% |
| SDC2 Methylation with Negative control | Chr8:97506434-97506502(hg19) | 0.19% | ||||
| Single positive TFPI2 segment-High Positive methylation reference-2 | CBPE0412-13 | TFPI2 High Positive methylation reference，SDC2 Negative methylation | TFPI2 Methylation Reference Standard with 10.00% | Chr7:93519461-93519624(hg19) | 10.94% | |
| SDC2 Methylation with Negative control | Chr8:97506434-97506502(hg19) | N/A | ||||
| Single positive TFPI2 segment-Low Positive methylation reference | CBPE0412-14 | TFPI2 Low Positive methylation reference，SDC2 Negative methylation | TFPI2 Methylation Reference Standard with 3.00% | Chr7:93519461-93519624(hg19) | N/A | |
| SDC2 Methylation with Negative control | Chr8:97506434-97506502(hg19) | N/A | ||||
| Single positive TFPI2 segment-LOD reference | CBPE0412-15 | TFPI2 LOD methylation reference，SDC2 Negative methylation | TFPI2 Methylation Reference Standard with 1.00% | Chr7:93519461-93519624(hg19) | 1.09% | |
| SDC2 Methylation with Negative control | Chr8:97506434-97506502(hg19) | N/A | ||||
| Single positive TFPI2 segment-Negative reference | CBPE0412-16 | Colorectal cancer-SDC2,TFPI2 Negative methylation | SDC2 Methylation with Negative control | Chr8:97506434-97506502(hg19) | N/A | |
| TFPI2 Methylation with Negative control | Chr7:93519461-93519624(hg19) | N/A | ||||
| Single positive TFPI2 segment-Precision reference | CBPE0412-17 | TFPI2 Low Positive methylation reference，SDC2 Negative methylation | TFPI2 Methylation Reference Standard with 3.00% | Chr7:93519461-93519624(hg19) | N/A | |
| SDC2 Methylation with Negative control | Chr8:97506434-97506502(hg19) | N/A | ||||
| CBPE0412-18 | Colorectal cancer-SDC2,TFPI2 Negative methylation | SDC2 Methylation with Negative control | Chr8:97506434-97506502(hg19) | N/A | ||
| TFPI2 Methylation with Negative control | Chr7:93519461-93519624(hg19) | N/A | ||||
| Remark | 1.Quality control products are also called accuracy standards and are used for qualitative judgment; 2. Reference products are used for qualitative and quantitative judgments. The judgment of strong positive, weak positive, detection limit, precision and specificity depends on the specific project. The judgment of this product is only an internal standard; 3. Quality control products are used for performance evaluation, factory inspection, and daily detection and judgment of test kits. Reference products are used for performance evaluation and factory inspection; 4. The above products only show part of the results, and the degree of methylation can be customized. | |||||
Product Application
SDC2/TFPI2 methylation quality control products are primarily used for quality control during fecal DNA methylation testing to ensure the accuracy, reliability, and comparability of test results. Key application scenarios include:
① Internal Quality Control in Clinical Laboratories: When conducting SDC2/TFPI2 gene methylation testing, laboratories must regularly run quality control products to monitor the stability of the testing process, including the efficiency of nucleic acid extraction, bisulfite conversion, and PCR amplification.
② Test Kit Performance Validation and Evaluation: When applying for registration for a new test kit or when introducing a new brand of reagents in a laboratory, quality control products must be used for performance validation, assessing factors such as compliance rate, detection limit, precision (intra- and inter-batch coefficient of variation), and interference tolerance.5
③ External Quality Evaluation: Standardized quality control products are issued by authoritative organizations to assess the consistency and accuracy of test results across laboratories.
④ Staff Training and Operation Standardization: When training new staff or standardizing operational procedures, the use of quality control products can help operators familiarize themselves with the process and interpret results.
Product Description
In colorectal cancer (CRC), methylation of the SDC2 (Syndecan-2) and TFPI2 (Tissue Factor Pathway Inhibitor 2) genes is a common early molecular event.
Under normal circumstances, the promoter regions of these two genes are unmethylated, allowing normal gene expression. The SDC2 protein is involved in processes such as cell proliferation and adhesion, while TFPI2 is a tumor suppressor gene whose protein product inhibits tumor invasion and metastasis. Hypermethylation of the promoter regions of these genes leads to transcriptional silencing, abolishing their normal tumor suppressor function1, thereby promoting the development and progression of colorectal cancer. Therefore, monitoring the methylation status of these genes can effectively detect early signals of colorectal cancer and its precancerous lesions, such as adenomas.
This package contains multiple detection samples for Colorectal cancer, We use simulated clinical cell lines to prepare them. If you are testing SDC2/TFPI2, you can choose this product.
General information
| Name | Package-Ref™ Colorectal cancer SDC2/TFPI2 for Methylation control |
| Cat. No. | CBPE0412 |
| Format | Genomic DNA |
| Size | 1ug |
| Buffer | Tris-EDTA |
| Intended Use | Research Use Only |
| Concentration | Download for COA |
| Purity | Download for COA |
| DNA electrophoresis | Download for COA |
| Storage Conditions | 2~8℃ |
| Expiry | 36 months from the date of manufacture |
| Remark | The data in the instruction manual is the data of a single test, and the specific data of each batch is subject to delivery. |
Technical Data
| Classification | Cat No. | Name | Description | Region | Methylation level | |
| quality control standard | CBPE0412-1 | Colorectal cancer-SDC2,TFPI2 Positive methylation | SDC2 Methylation with Positive control | Chr8:97506434-97506502(hg19) | N/A | |
| TFPI2 Methylation with Positive control | Chr7:93519461-93519624(hg19) | N/A | ||||
| CBPE0412-2 | Colorectal cancer-SDC2,TFPI2 Negative methylation | SDC2 Methylation with Negative control | Chr8:97506434-97506502(hg19) | N/A | ||
| TFPI2 Methylation with Negative control | Chr7:93519461-93519624(hg19) | N/A | ||||
| CBPE0412-3 | Colorectal cancer-SDC2 Negative methylation，TFPI2 Positive methylation | SDC2 Methylation with Negative control | Chr8:97506434-97506502(hg19) | 0.19% | ||
| TFPI2 Methylation with Positive control | Chr7:93519461-93519624(hg19) | 33.09% | ||||
| CBPE0412-4 | Colorectal cancer-TFPI2 Negative methylation，SDC2 Positive methylation | SDC2 Methylation with Positive control | Chr8:97506434-97506502(hg19) | 49.09% | ||
| TFPI2 Methylation with Negative control | Chr7:93519461-93519624(hg19) | 0.08% | ||||
| Classification | Cat No. | Name | Description | Region | Methylation level | |
| Single positive SDC2-reference standard | Single positive SDC2 segment-High Positive reference-1 | CBPE0412-5 | SDC2 High Positive methylation reference，TFPI2 Negative methylation | SDC2 Methylation Reference Standard with 45.00% | Chr8:97506434-97506502(hg19) | 49.09% |
| TFPI2 Methylation with Negative control | Chr7:93519461-93519624(hg19) | 0.08% | ||||
| Single positive SDC2 segment-High Positive reference-2 | CBPE0412-6 | SDC2 High Positive methylation reference，TFPI2 Negative methylation | SDC2 Methylation Reference Standard with 10.00% | Chr8:97506434-97506502(hg19) | 9.12% | |
| TFPI2 Methylation Negative Reference Standard | Chr7:93519461-93519624(hg19) | N/A | ||||
| Single positive SDC2 segment-Low Positive reference | CBPE0412-7 | SDC2 Low Positive methylation reference，TFPI2 Negative methylation | SDC2 Methylation Reference Standard with 3.00% | Chr8:97506434-97506502(hg19) | N/A | |
| TFPI2 Methylation Negative Reference Standard | Chr7:93519461-93519624(hg19) | N/A | ||||
| Single positive SDC2 segment-LOD reference | CBPE0412-8 | SDC2 LOD reference，TFPI2 Negative methylation | SDC2 Methylation Reference Standard with 1.00% | Chr8:97506434-97506502(hg19) | 1.17% | |
| TFPI2 Methylation Negative Reference Standard | Chr7:93519461-93519624(hg19) | N/A | ||||
| Single positive SDC2 segment-Negative methylation | CBPE0412-9 | Colorectal cancer-SDC2,TFPI2 Negative methylation | SDC2 Methylation with Negative control | Chr8:97506434-97506502(hg19) | N/A | |
| TFPI2 Methylation with Negative control | Chr7:93519461-93519624(hg19) | N/A | ||||
| Single positive SDC2 segment-precision reference | CBPE0412-10 | SDC2 Low Positive methylation reference,TFPI2 Negative methylation | SDC2 Methylation Reference Standard with 3.00% | Chr8:97506434-97506502(hg19) | N/A | |
| TFPI2 Methylation Negative Reference Standard | Chr7:93519461-93519624(hg19) | N/A | ||||
| CBPE0412-11 | Colorectal cancer-SDC2,TFPI2 Negative methylation | SDC2 Methylation with Negative control | Chr8:97506434-97506502(hg19) | N/A | ||
| TFPI2 Methylation with Negative control | Chr7:93519461-93519624(hg19) | N/A | ||||
| Classification | Cat No. | Name | Description | Region | Methylation level | |
| Single positiveTFPI2-reference standard | Single positive TFPI2 segment-High Positive methylation reference-1 | CBPE0412-12 | TFPI2 High Positive methylation reference，SDC2 Negative methylation | TFPI2 Methylation Reference Standard with 30.00% | Chr7:93519461-93519624(hg19) | 33.09% |
| SDC2 Methylation with Negative control | Chr8:97506434-97506502(hg19) | 0.19% | ||||
| Single positive TFPI2 segment-High Positive methylation reference-2 | CBPE0412-13 | TFPI2 High Positive methylation reference，SDC2 Negative methylation | TFPI2 Methylation Reference Standard with 10.00% | Chr7:93519461-93519624(hg19) | 10.94% | |
| SDC2 Methylation with Negative control | Chr8:97506434-97506502(hg19) | N/A | ||||
| Single positive TFPI2 segment-Low Positive methylation reference | CBPE0412-14 | TFPI2 Low Positive methylation reference，SDC2 Negative methylation | TFPI2 Methylation Reference Standard with 3.00% | Chr7:93519461-93519624(hg19) | N/A | |
| SDC2 Methylation with Negative control | Chr8:97506434-97506502(hg19) | N/A | ||||
| Single positive TFPI2 segment-LOD reference | CBPE0412-15 | TFPI2 LOD methylation reference，SDC2 Negative methylation | TFPI2 Methylation Reference Standard with 1.00% | Chr7:93519461-93519624(hg19) | 1.09% | |
| SDC2 Methylation with Negative control | Chr8:97506434-97506502(hg19) | N/A | ||||
| Single positive TFPI2 segment-Negative reference | CBPE0412-16 | Colorectal cancer-SDC2,TFPI2 Negative methylation | SDC2 Methylation with Negative control | Chr8:97506434-97506502(hg19) | N/A | |
| TFPI2 Methylation with Negative control | Chr7:93519461-93519624(hg19) | N/A | ||||
| Single positive TFPI2 segment-Precision reference | CBPE0412-17 | TFPI2 Low Positive methylation reference，SDC2 Negative methylation | TFPI2 Methylation Reference Standard with 3.00% | Chr7:93519461-93519624(hg19) | N/A | |
| SDC2 Methylation with Negative control | Chr8:97506434-97506502(hg19) | N/A | ||||
| CBPE0412-18 | Colorectal cancer-SDC2,TFPI2 Negative methylation | SDC2 Methylation with Negative control | Chr8:97506434-97506502(hg19) | N/A | ||
| TFPI2 Methylation with Negative control | Chr7:93519461-93519624(hg19) | N/A | ||||
| Remark | 1.Quality control products are also called accuracy standards and are used for qualitative judgment; 2. Reference products are used for qualitative and quantitative judgments. The judgment of strong positive, weak positive, detection limit, precision and specificity depends on the specific project. The judgment of this product is only an internal standard; 3. Quality control products are used for performance evaluation, factory inspection, and daily detection and judgment of test kits. Reference products are used for performance evaluation and factory inspection; 4. The above products only show part of the results, and the degree of methylation can be customized. | |||||
Product Application
SDC2/TFPI2 methylation quality control products are primarily used for quality control during fecal DNA methylation testing to ensure the accuracy, reliability, and comparability of test results. Key application scenarios include:
① Internal Quality Control in Clinical Laboratories: When conducting SDC2/TFPI2 gene methylation testing, laboratories must regularly run quality control products to monitor the stability of the testing process, including the efficiency of nucleic acid extraction, bisulfite conversion, and PCR amplification.
② Test Kit Performance Validation and Evaluation: When applying for registration for a new test kit or when introducing a new brand of reagents in a laboratory, quality control products must be used for performance validation, assessing factors such as compliance rate, detection limit, precision (intra- and inter-batch coefficient of variation), and interference tolerance.5
③ External Quality Evaluation: Standardized quality control products are issued by authoritative organizations to assess the consistency and accuracy of test results across laboratories.
④ Staff Training and Operation Standardization: When training new staff or standardizing operational procedures, the use of quality control products can help operators familiarize themselves with the process and interpret results.
General information
Name | Package-Ref™ Colorectal cancer SDC2/TFPI2 for Methylation control |
Cat. No. | CBPE0412 |
Format | Genomic DNA |
Size | 1ug |
Buffer | Tris-EDTA |
Intended Use | Research Use Only |
Concentration | Download for COA |
Purity | Download for COA |
DNA electrophoresis | Download for COA |
Storage Conditions | 2~8℃ |
Expiry | 36 months from the date of manufacture |
Remark | The data in the instruction manual is the data of a single test, and the specific data of each batch is subject to delivery. |
General information
Name | Package-Ref™ Colorectal cancer SDC2/TFPI2 for Methylation control |
Cat. No. | CBPE0412 |
Format | Genomic DNA |
Size | 1ug |
Buffer | Tris-EDTA |
Intended Use | Research Use Only |
Concentration | Download for COA |
Purity | Download for COA |
DNA electrophoresis | Download for COA |
Storage Conditions | 2~8℃ |
Expiry | 36 months from the date of manufacture |
Remark | The data in the instruction manual is the data of a single test, and the specific data of each batch is subject to delivery. |
Technical Data
Classification | Cat No. | Name | Description | Region | Methylation level | |
quality control standard | CBPE0412-1 | Colorectal cancer-SDC2,TFPI2 Positive methylation | SDC2 Methylation with Positive control | Chr8:97506434-97506502(hg19) | N/A | |
TFPI2 Methylation with Positive control | Chr7:93519461-93519624(hg19) | N/A | ||||
CBPE0412-2 | Colorectal cancer-SDC2,TFPI2 Negative methylation | SDC2 Methylation with Negative control | Chr8:97506434-97506502(hg19) | N/A | ||
TFPI2 Methylation with Negative control | Chr7:93519461-93519624(hg19) | N/A | ||||
CBPE0412-3 | Colorectal cancer-SDC2 Negative methylation，TFPI2 Positive methylation | SDC2 Methylation with Negative control | Chr8:97506434-97506502(hg19) | 0.19% | ||
TFPI2 Methylation with Positive control | Chr7:93519461-93519624(hg19) | 33.09% | ||||
CBPE0412-4 | Colorectal cancer-TFPI2 Negative methylation，SDC2 Positive methylation | SDC2 Methylation with Positive control | Chr8:97506434-97506502(hg19) | 49.09% | ||
TFPI2 Methylation with Negative control | Chr7:93519461-93519624(hg19) | 0.08% | ||||
Classification | Cat No. | Name | Description | Region | Methylation level | |
Single positive SDC2-reference standard | Single positive SDC2 segment-High Positive reference-1 | CBPE0412-5 | SDC2 High Positive methylation reference，TFPI2 Negative methylation | SDC2 Methylation Reference Standard with 45.00% | Chr8:97506434-97506502(hg19) | 49.09% |
TFPI2 Methylation with Negative control | Chr7:93519461-93519624(hg19) | 0.08% | ||||
Single positive SDC2 segment-High Positive reference-2 | CBPE0412-6 | SDC2 High Positive methylation reference，TFPI2 Negative methylation | SDC2 Methylation Reference Standard with 10.00% | Chr8:97506434-97506502(hg19) | 9.12% | |
TFPI2 Methylation Negative Reference Standard | Chr7:93519461-93519624(hg19) | N/A | ||||
Single positive SDC2 segment-Low Positive reference | CBPE0412-7 | SDC2 Low Positive methylation reference，TFPI2 Negative methylation | SDC2 Methylation Reference Standard with 3.00% | Chr8:97506434-97506502(hg19) | N/A | |
TFPI2 Methylation Negative Reference Standard | Chr7:93519461-93519624(hg19) | N/A | ||||
Single positive SDC2 segment-LOD reference | CBPE0412-8 | SDC2 LOD reference，TFPI2 Negative methylation | SDC2 Methylation Reference Standard with 1.00% | Chr8:97506434-97506502(hg19) | 1.17% | |
TFPI2 Methylation Negative Reference Standard | Chr7:93519461-93519624(hg19) | N/A | ||||
Single positive SDC2 segment-Negative methylation | CBPE0412-9 | Colorectal cancer-SDC2,TFPI2 Negative methylation | SDC2 Methylation with Negative control | Chr8:97506434-97506502(hg19) | N/A | |
TFPI2 Methylation with Negative control | Chr7:93519461-93519624(hg19) | N/A | ||||
Single positive SDC2 segment-precision reference | CBPE0412-10 | SDC2 Low Positive methylation reference,TFPI2 Negative methylation | SDC2 Methylation Reference Standard with 3.00% | Chr8:97506434-97506502(hg19) | N/A | |
TFPI2 Methylation Negative Reference Standard | Chr7:93519461-93519624(hg19) | N/A | ||||
CBPE0412-11 | Colorectal cancer-SDC2,TFPI2 Negative methylation | SDC2 Methylation with Negative control | Chr8:97506434-97506502(hg19) | N/A | ||
TFPI2 Methylation with Negative control | Chr7:93519461-93519624(hg19) | N/A | ||||
Classification | Cat No. | Name | Description | Region | Methylation level | |
Single positiveTFPI2-reference standard | Single positive TFPI2 segment-High Positive methylation reference-1 | CBPE0412-12 | TFPI2 High Positive methylation reference，SDC2 Negative methylation | TFPI2 Methylation Reference Standard with 30.00% | Chr7:93519461-93519624(hg19) | 33.09% |
SDC2 Methylation with Negative control | Chr8:97506434-97506502(hg19) | 0.19% | ||||
Single positive TFPI2 segment-High Positive methylation reference-2 | CBPE0412-13 | TFPI2 High Positive methylation reference，SDC2 Negative methylation | TFPI2 Methylation Reference Standard with 10.00% | Chr7:93519461-93519624(hg19) | 10.94% | |
SDC2 Methylation with Negative control | Chr8:97506434-97506502(hg19) | N/A | ||||
Single positive TFPI2 segment-Low Positive methylation reference | CBPE0412-14 | TFPI2 Low Positive methylation reference，SDC2 Negative methylation | TFPI2 Methylation Reference Standard with 3.00% | Chr7:93519461-93519624(hg19) | N/A | |
SDC2 Methylation with Negative control | Chr8:97506434-97506502(hg19) | N/A | ||||
Single positive TFPI2 segment-LOD reference | CBPE0412-15 | TFPI2 LOD methylation reference，SDC2 Negative methylation | TFPI2 Methylation Reference Standard with 1.00% | Chr7:93519461-93519624(hg19) | 1.09% | |
SDC2 Methylation with Negative control | Chr8:97506434-97506502(hg19) | N/A | ||||
Single positive TFPI2 segment-Negative reference | CBPE0412-16 | Colorectal cancer-SDC2,TFPI2 Negative methylation | SDC2 Methylation with Negative control | Chr8:97506434-97506502(hg19) | N/A | |
TFPI2 Methylation with Negative control | Chr7:93519461-93519624(hg19) | N/A | ||||
Single positive TFPI2 segment-Precision reference | CBPE0412-17 | TFPI2 Low Positive methylation reference，SDC2 Negative methylation | TFPI2 Methylation Reference Standard with 3.00% | Chr7:93519461-93519624(hg19) | N/A | |
SDC2 Methylation with Negative control | Chr8:97506434-97506502(hg19) | N/A | ||||
CBPE0412-18 | Colorectal cancer-SDC2,TFPI2 Negative methylation | SDC2 Methylation with Negative control | Chr8:97506434-97506502(hg19) | N/A | ||
TFPI2 Methylation with Negative control | Chr7:93519461-93519624(hg19) | N/A | ||||
Remark | 1.Quality control products are also called accuracy standards and are used for qualitative judgment; 2. Reference products are used for qualitative and quantitative judgments. The judgment of strong positive, weak positive, detection limit, precision and specificity depends on the specific project. The judgment of this product is only an internal standard; 3. Quality control products are used for performance evaluation, factory inspection, and daily detection and judgment of test kits. Reference products are used for performance evaluation and factory inspection; 4. The above products only show part of the results, and the degree of methylation can be customized. | |||||
Technical Data
Classification | Cat No. | Name | Description | Region | Methylation level | |
quality control standard | CBPE0412-1 | Colorectal cancer-SDC2,TFPI2 Positive methylation | SDC2 Methylation with Positive control | Chr8:97506434-97506502(hg19) | N/A | |
TFPI2 Methylation with Positive control | Chr7:93519461-93519624(hg19) | N/A | ||||
CBPE0412-2 | Colorectal cancer-SDC2,TFPI2 Negative methylation | SDC2 Methylation with Negative control | Chr8:97506434-97506502(hg19) | N/A | ||
TFPI2 Methylation with Negative control | Chr7:93519461-93519624(hg19) | N/A | ||||
CBPE0412-3 | Colorectal cancer-SDC2 Negative methylation，TFPI2 Positive methylation | SDC2 Methylation with Negative control | Chr8:97506434-97506502(hg19) | 0.19% | ||
TFPI2 Methylation with Positive control | Chr7:93519461-93519624(hg19) | 33.09% | ||||
CBPE0412-4 | Colorectal cancer-TFPI2 Negative methylation，SDC2 Positive methylation | SDC2 Methylation with Positive control | Chr8:97506434-97506502(hg19) | 49.09% | ||
TFPI2 Methylation with Negative control | Chr7:93519461-93519624(hg19) | 0.08% | ||||
Classification | Cat No. | Name | Description | Region | Methylation level | |
Single positive SDC2-reference standard | Single positive SDC2 segment-High Positive reference-1 | CBPE0412-5 | SDC2 High Positive methylation reference，TFPI2 Negative methylation | SDC2 Methylation Reference Standard with 45.00% | Chr8:97506434-97506502(hg19) | 49.09% |
TFPI2 Methylation with Negative control | Chr7:93519461-93519624(hg19) | 0.08% | ||||
Single positive SDC2 segment-High Positive reference-2 | CBPE0412-6 | SDC2 High Positive methylation reference，TFPI2 Negative methylation | SDC2 Methylation Reference Standard with 10.00% | Chr8:97506434-97506502(hg19) | 9.12% | |
TFPI2 Methylation Negative Reference Standard | Chr7:93519461-93519624(hg19) | N/A | ||||
Single positive SDC2 segment-Low Positive reference | CBPE0412-7 | SDC2 Low Positive methylation reference，TFPI2 Negative methylation | SDC2 Methylation Reference Standard with 3.00% | Chr8:97506434-97506502(hg19) | N/A | |
TFPI2 Methylation Negative Reference Standard | Chr7:93519461-93519624(hg19) | N/A | ||||
Single positive SDC2 segment-LOD reference | CBPE0412-8 | SDC2 LOD reference，TFPI2 Negative methylation | SDC2 Methylation Reference Standard with 1.00% | Chr8:97506434-97506502(hg19) | 1.17% | |
TFPI2 Methylation Negative Reference Standard | Chr7:93519461-93519624(hg19) | N/A | ||||
Single positive SDC2 segment-Negative methylation | CBPE0412-9 | Colorectal cancer-SDC2,TFPI2 Negative methylation | SDC2 Methylation with Negative control | Chr8:97506434-97506502(hg19) | N/A | |
TFPI2 Methylation with Negative control | Chr7:93519461-93519624(hg19) | N/A | ||||
Single positive SDC2 segment-precision reference | CBPE0412-10 | SDC2 Low Positive methylation reference,TFPI2 Negative methylation | SDC2 Methylation Reference Standard with 3.00% | Chr8:97506434-97506502(hg19) | N/A | |
TFPI2 Methylation Negative Reference Standard | Chr7:93519461-93519624(hg19) | N/A | ||||
CBPE0412-11 | Colorectal cancer-SDC2,TFPI2 Negative methylation | SDC2 Methylation with Negative control | Chr8:97506434-97506502(hg19) | N/A | ||
TFPI2 Methylation with Negative control | Chr7:93519461-93519624(hg19) | N/A | ||||
Classification | Cat No. | Name | Description | Region | Methylation level | |
Single positiveTFPI2-reference standard | Single positive TFPI2 segment-High Positive methylation reference-1 | CBPE0412-12 | TFPI2 High Positive methylation reference，SDC2 Negative methylation | TFPI2 Methylation Reference Standard with 30.00% | Chr7:93519461-93519624(hg19) | 33.09% |
SDC2 Methylation with Negative control | Chr8:97506434-97506502(hg19) | 0.19% | ||||
Single positive TFPI2 segment-High Positive methylation reference-2 | CBPE0412-13 | TFPI2 High Positive methylation reference，SDC2 Negative methylation | TFPI2 Methylation Reference Standard with 10.00% | Chr7:93519461-93519624(hg19) | 10.94% | |
SDC2 Methylation with Negative control | Chr8:97506434-97506502(hg19) | N/A | ||||
Single positive TFPI2 segment-Low Positive methylation reference | CBPE0412-14 | TFPI2 Low Positive methylation reference，SDC2 Negative methylation | TFPI2 Methylation Reference Standard with 3.00% | Chr7:93519461-93519624(hg19) | N/A | |
SDC2 Methylation with Negative control | Chr8:97506434-97506502(hg19) | N/A | ||||
Single positive TFPI2 segment-LOD reference | CBPE0412-15 | TFPI2 LOD methylation reference，SDC2 Negative methylation | TFPI2 Methylation Reference Standard with 1.00% | Chr7:93519461-93519624(hg19) | 1.09% | |
SDC2 Methylation with Negative control | Chr8:97506434-97506502(hg19) | N/A | ||||
Single positive TFPI2 segment-Negative reference | CBPE0412-16 | Colorectal cancer-SDC2,TFPI2 Negative methylation | SDC2 Methylation with Negative control | Chr8:97506434-97506502(hg19) | N/A | |
TFPI2 Methylation with Negative control | Chr7:93519461-93519624(hg19) | N/A | ||||
Single positive TFPI2 segment-Precision reference | CBPE0412-17 | TFPI2 Low Positive methylation reference，SDC2 Negative methylation | TFPI2 Methylation Reference Standard with 3.00% | Chr7:93519461-93519624(hg19) | N/A | |
SDC2 Methylation with Negative control | Chr8:97506434-97506502(hg19) | N/A | ||||
CBPE0412-18 | Colorectal cancer-SDC2,TFPI2 Negative methylation | SDC2 Methylation with Negative control | Chr8:97506434-97506502(hg19) | N/A | ||
TFPI2 Methylation with Negative control | Chr7:93519461-93519624(hg19) | N/A | ||||
Remark | 1.Quality control products are also called accuracy standards and are used for qualitative judgment; 2. Reference products are used for qualitative and quantitative judgments. The judgment of strong positive, weak positive, detection limit, precision and specificity depends on the specific project. The judgment of this product is only an internal standard; 3. Quality control products are used for performance evaluation, factory inspection, and daily detection and judgment of test kits. Reference products are used for performance evaluation and factory inspection; 4. The above products only show part of the results, and the degree of methylation can be customized. | |||||
Product Application
SDC2/TFPI2 methylation quality control products are primarily used for quality control during fecal DNA methylation testing to ensure the accuracy, reliability, and comparability of test results. Key application scenarios include:
① Internal Quality Control in Clinical Laboratories: When conducting SDC2/TFPI2 gene methylation testing, laboratories must regularly run quality control products to monitor the stability of the testing process, including the efficiency of nucleic acid extraction, bisulfite conversion, and PCR amplification.
② Test Kit Performance Validation and Evaluation: When applying for registration for a new test kit or when introducing a new brand of reagents in a laboratory, quality control products must be used for performance validation, assessing factors such as compliance rate, detection limit, precision (intra- and inter-batch coefficient of variation), and interference tolerance.5
③ External Quality Evaluation: Standardized quality control products are issued by authoritative organizations to assess the consistency and accuracy of test results across laboratories.
④ Staff Training and Operation Standardization: When training new staff or standardizing operational procedures, the use of quality control products can help operators familiarize themselves with the process and interpret results.
Product Application
SDC2/TFPI2 methylation quality control products are primarily used for quality control during fecal DNA methylation testing to ensure the accuracy, reliability, and comparability of test results. Key application scenarios include:
① Internal Quality Control in Clinical Laboratories: When conducting SDC2/TFPI2 gene methylation testing, laboratories must regularly run quality control products to monitor the stability of the testing process, including the efficiency of nucleic acid extraction, bisulfite conversion, and PCR amplification.
② Test Kit Performance Validation and Evaluation: When applying for registration for a new test kit or when introducing a new brand of reagents in a laboratory, quality control products must be used for performance validation, assessing factors such as compliance rate, detection limit, precision (intra- and inter-batch coefficient of variation), and interference tolerance.5
③ External Quality Evaluation: Standardized quality control products are issued by authoritative organizations to assess the consistency and accuracy of test results across laboratories.
④ Staff Training and Operation Standardization: When training new staff or standardizing operational procedures, the use of quality control products can help operators familiarize themselves with the process and interpret results.
