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HLA matching multi-locus genotyping standard

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Based on different testing needs in the market, CB-Gene has developed HLA standards that can be used for the development of HLA nucleic acid testing kits and quality control of HLA genotyping testing.
 

  • CBPQ000-7/8/10/12/13/14

  • CBPQ000-7/8/10/12/13/14

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Description

To help establish an accurate assay for HLA typing, CB- Gene has launched HLA single-locus genotyping (4-digit HLA alleles) and HLA matching multi-locus genotyping (6-digit HLA alleles) standard products.

HLA matching multi-locus genotyping standard cover a relatively complete set of 11 loci A、B、C、 DRB1/3/4/5 、DPA1 、DPB1 、DQA1 、DQB1 verified by third-generation sequencing, with ultra-high resolution typing, which can accurately confirm the typing sequence. This type of product plays a key role in donorrecipient matching for bone marrow transplantation and other tissue and organ transplants such as liver and kidney. The HLA genotype matching degree of both donors and recipients significantly affects the long-term survival rate of the transplant recipients. The higher the degree of matching,the better. , the higher the long-term survival rate.


Test Principle

HLA Reference products have been tested using sanger sequencing、PCR-SBT or third-generation sequencing. By seguence-alignment with IMGT/HLA database sequence,we accurately confirm the genotypes of every sample


Technical Data

HLA matching multi-locus genotyping standard Ⅰ CBPQ0007

Catalog No.

HLA-A

HLA-B

HLA-C

HLA-DQA1

HLA-DQB1

CBPQ0007

HLA-A*02:06:01  HLA-A*31:01:02

HLA-B*46:01:01  HLA-B*40:02:01

HLA-C*01:02:01  HLA-C*03:04:01

HLA-DQA1*03:01:01  HLA-DQA1*05:03:01

HLA-DQB1*03:02:01  HLA-DQB1*03:01:01

HLA-DPA1

HLA-DPB1

HLA-DRB1

HLA-DRB3/4/5

Vrification method

HLA-DPA1*02:02:02 HLA-DPA1*01:03:01

HLA-DPB1*05:01:01  HLA-DPB1*02:01:02

HLA-DRB1*14:03:01  HLA-DRB1*04:07:01

HLA-DRB3*01:01:02  HLA-DRB4*01:03:01

Third-generation    sequencin

 

HLA matching multi-locus genotyping standard Ⅱ CBPQ0008

Catalog No.

HLA-A

HLA-B

HLA-C

HLA-DQA1

HLA-DQB1

CBPQ0008

HLA-A*03:01:01  HLA-A*11:01:01

HLA-B*56:01:01 HLA-B*44:02:01

HLA-C*01:02:01  HLA-C*05:01:01

HLA-DQA1*01:01:01  HLA-DQA1*05:05:01

HLA-DQB1*05:01:01  HLA-DQB1*03:01:01

HLA-DPA1

HLA-DPB1

HLA-DRB1

HLA-DRB3/4/5

Vrification method

HLA-DPA1*01:03:01 HLA-DPA1*01:03:01

HLA-DPB1*02:01:02 HLA-DPB1*03:01:01

HLA-DRB1*12:01:01 HLA-DRB1*01:01:01

HLA-DRB3*02:02:01

Third-generation      sequencin

 

HLA matching multi-locus genotyping standard Ⅲ CBPQ0010

Catalog No.

HLA-A

HLA-B

HLA-C

HLA-DQA1

HLA-DQB1

CBPQ0010

HLA-A*26:01:01  HLA-A*26:02:01

HLA-B*48:01:01  HLA-B*40:06:01

HLA-C*08:01:01  HLA-C*03:03:01

HLA-DQA1*03:02:01  HLA-DQA1*01:04:01

HLA-DQB1*05:03:01  HLA-DQB1*03:03:02

HLA-DPA1

HLA-DPB1

HLA-DRB1

HLA-DRB3/4/5

Vrification method

HLA-DPA1*01:03:01 HLA-DPA1*01:03:01

HLA-DPB1*02:01:02 HLA-DPB1*02:01:02

HLA-DRB1*14:54:01 HLA-DRB1*09:01:02

HLA-DRB3*02:02:01  HLA-DRB4*01:03:02

Third-generation      sequencin


HLA matching multi-locus genotyping standard Ⅳ-Son CBPQ0012

Catalog No.

HLA-A

HLA-B

HLA-C

HLA-DQA1

HLA-DQB1

CBPQ0012

HLA-A*02:01:01  HLA-A*03:01:01

HLA-B*15:01:01  HLA-B*40:02:01

HLA-C*01:02:01  HLA-C*03:03:01

HLA-DQA1*02:01:01  HLA-DQA1*05:05:01

HLA-DQB1*03:01:01  HLA-DQB1*02:02:01

HLA-DPA1

HLA-DPB1

HLA-DRB1

HLA-DRB3/4/5

Vrification method

HLA-DPA1*01:03:01 HLA-DPA1*01:03:01

HLA-DPB1*04:01:01 HLA-DPB1*02:01:02

HLA-DRB1*11:01:01 HLA-DRB1*07:01:01

HLA-DRB3*02:02:01    HLA-DRB4*01:03:01

Third-generation      sequencin


HLA matching multi-locus genotyping standard Ⅳ-Monther CBPQ0013

Catalog No.

HLA-A

HLA-B

HLA-C

HLA-DQA1

HLA-DQB1

CBPQ0013

HLA-A*03:01:01  HLA-A*01:01:01

HLA-B*51:01:01  HLA-B*08:01:01

HLA-C*01:02:01  HLA-C*07:01:01

HLA-DQA1*02:01:01  HLA-DQA1*05:01:01

HLA-DQB1*02:01:01  HLA-DQB1*02:02:01

HLA-DPA1

HLA-DPB1

HLA-DRB1

HLA-DRB3/4/5

Vrification method

HLA-DPA1*01:03:01 HLA-DPA1*01:03:01

HLA-DPB1*03:01:01 HLA-DPB1*04:01:01

HLA-DRB1*03:01:01 HLA-DRB1*07:01:01

HLA-DRB3*01:01:02  HLA-DRB4*01:03:01

Third-generation      sequencin


HLA matching multi-locus genotyping standard Ⅳ-Daughter CBPQ0014

Catalog No.

HLA-A

HLA-B

HLA-C

HLA-DQA1

HLA-DQB1

CBPQ0014

HLA-A*03:01:01  HLA-A*01:01:01

HLA-B*39:06:02  HLA-B*08:01:01

HLA-C*07:02:01  HLA-C*07:01:01

HLA-DQA1*05:01:01  HLA-DQA1*01:01:01

HLA-DQB1*05:01:01  HLA-DQB1*02:01:01

HLA-DPA1

HLA-DPB1

HLA-DRB1

HLA-DRB3/4/5

Vrification method

HLA-DPA1*01:03:01 HLA-DPA1*01:03:01

HLA-DPB1*03:01:01 HLA-DPB1*04:01:01

HLA-DRB1*03:01:01 HLA-DRB1*01:01:01

HLA-DRB3*01:01:02

Third-generation      sequencin


Advantages

  • CB-Gene launched HLA standard products have a human cell background, better simulate clinical samples,and have the advantages of reproducibility, sustainable and stable supply, and small batch-to-batch differences.

  • CB-Gene has passed ISO90001 and ISO13485 dual system certification, and its product quality is undoubtedly.





Test Principle

HLA Reference products have been tested using sanger sequencing、PCR-SBT or third-generation sequencing. By seguence-alignment with IMGT/HLA database sequence,we accurately confirm the genotypes of every sample.

Technical Data

HLA matching multi-locus genotyping standard Ⅰ CBPQ0007

Catalog No.

HLA-A

HLA-B

HLA-C

HLA-DQA1

HLA-DQB1

CBPQ0007

HLA-A*02:06:01  HLA-A*31:01:02

HLA-B*46:01:01  HLA-B*40:02:01

HLA-C*01:02:01  HLA-C*03:04:01

HLA-DQA1*03:01:01  HLA-DQA1*05:03:01

HLA-DQB1*03:02:01  HLA-DQB1*03:01:01

HLA-DPA1

HLA-DPB1

HLA-DRB1

HLA-DRB3/4/5

Vrification method

HLA-DPA1*02:02:02 HLA-DPA1*01:03:01

HLA-DPB1*05:01:01  HLA-DPB1*02:01:02

HLA-DRB1*14:03:01  HLA-DRB1*04:07:01

HLA-DRB3*01:01:02  HLA-DRB4*01:03:01

Third-generation    sequencin

 

HLA matching multi-locus genotyping standard Ⅱ CBPQ0008

Catalog No.

HLA-A

HLA-B

HLA-C

HLA-DQA1

HLA-DQB1

CBPQ0008

HLA-A*03:01:01  HLA-A*11:01:01

HLA-B*56:01:01 HLA-B*44:02:01

HLA-C*01:02:01  HLA-C*05:01:01

HLA-DQA1*01:01:01  HLA-DQA1*05:05:01

HLA-DQB1*05:01:01  HLA-DQB1*03:01:01

HLA-DPA1

HLA-DPB1

HLA-DRB1

HLA-DRB3/4/5

Vrification method

HLA-DPA1*01:03:01 HLA-DPA1*01:03:01

HLA-DPB1*02:01:02 HLA-DPB1*03:01:01

HLA-DRB1*12:01:01 HLA-DRB1*01:01:01

HLA-DRB3*02:02:01

Third-generation      sequencin

 

HLA matching multi-locus genotyping standard Ⅲ CBPQ0010

Catalog No.

HLA-A

HLA-B

HLA-C

HLA-DQA1

HLA-DQB1

CBPQ0010

HLA-A*26:01:01  HLA-A*26:02:01

HLA-B*48:01:01  HLA-B*40:06:01

HLA-C*08:01:01  HLA-C*03:03:01

HLA-DQA1*03:02:01  HLA-DQA1*01:04:01

HLA-DQB1*05:03:01  HLA-DQB1*03:03:02

HLA-DPA1

HLA-DPB1

HLA-DRB1

HLA-DRB3/4/5

Vrification method

HLA-DPA1*01:03:01 HLA-DPA1*01:03:01

HLA-DPB1*02:01:02 HLA-DPB1*02:01:02

HLA-DRB1*14:54:01 HLA-DRB1*09:01:02

HLA-DRB3*02:02:01  HLA-DRB4*01:03:02

Third-generation      sequencin


HLA matching multi-locus genotyping standard Ⅳ-Son CBPQ0012

Catalog No.

HLA-A

HLA-B

HLA-C

HLA-DQA1

HLA-DQB1

CBPQ0012

HLA-A*02:01:01  HLA-A*03:01:01

HLA-B*15:01:01  HLA-B*40:02:01

HLA-C*01:02:01  HLA-C*03:03:01

HLA-DQA1*02:01:01  HLA-DQA1*05:05:01

HLA-DQB1*03:01:01  HLA-DQB1*02:02:01

HLA-DPA1

HLA-DPB1

HLA-DRB1

HLA-DRB3/4/5

Vrification method

HLA-DPA1*01:03:01 HLA-DPA1*01:03:01

HLA-DPB1*04:01:01 HLA-DPB1*02:01:02

HLA-DRB1*11:01:01 HLA-DRB1*07:01:01

HLA-DRB3*02:02:01    HLA-DRB4*01:03:01

Third-generation      sequencin


HLA matching multi-locus genotyping standard Ⅳ-Monther CBPQ0013

Catalog No.

HLA-A

HLA-B

HLA-C

HLA-DQA1

HLA-DQB1

CBPQ0013

HLA-A*03:01:01  HLA-A*01:01:01

HLA-B*51:01:01  HLA-B*08:01:01

HLA-C*01:02:01  HLA-C*07:01:01

HLA-DQA1*02:01:01  HLA-DQA1*05:01:01

HLA-DQB1*02:01:01  HLA-DQB1*02:02:01

HLA-DPA1

HLA-DPB1

HLA-DRB1

HLA-DRB3/4/5

Vrification method

HLA-DPA1*01:03:01 HLA-DPA1*01:03:01

HLA-DPB1*03:01:01 HLA-DPB1*04:01:01

HLA-DRB1*03:01:01 HLA-DRB1*07:01:01

HLA-DRB3*01:01:02  HLA-DRB4*01:03:01

Third-generation      sequencin


HLA matching multi-locus genotyping standard Ⅳ-Daughter CBPQ0014

Catalog No.

HLA-A

HLA-B

HLA-C

HLA-DQA1

HLA-DQB1

CBPQ0014

HLA-A*03:01:01  HLA-A*01:01:01

HLA-B*39:06:02  HLA-B*08:01:01

HLA-C*07:02:01  HLA-C*07:01:01

HLA-DQA1*05:01:01  HLA-DQA1*01:01:01

HLA-DQB1*05:01:01  HLA-DQB1*02:01:01

HLA-DPA1

HLA-DPB1

HLA-DRB1

HLA-DRB3/4/5

Vrification method

HLA-DPA1*01:03:01 HLA-DPA1*01:03:01

HLA-DPB1*03:01:01 HLA-DPB1*04:01:01

HLA-DRB1*03:01:01 HLA-DRB1*01:01:01

HLA-DRB3*01:01:02

Third-generation      sequencin



Advantages

  • CB-Gene launched HLA standard products have a human cell background, better simulate clinical samples,and have the advantages of reproducibility, sustainable and stable supply, and small batch-to-batch differences.

  • CB-Gene has passed ISO90001 and ISO13485 dual system certification, and its product quality is undoubtedly.


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