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CBPE0229-0235
CBPE0229-0235
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Product Description
The BMP3 (bone morphogenetic protein 3) gene encodes a secreted protein belonging to the TGF-β (transforming growth factor-β) superfamily. Alterations in the methylation status of this gene, particularly hypermethylation of the CpG island in its promoter region, can silence gene expression and is closely associated with the development and progression of various tumors.
Research has found that hypermethylation of the BMP3 gene occurs in:
·Colorectal cancer (CRC): In the majority of CRC cases, the BMP3 gene is hypermethylated and downregulated.
·Gastric cancer: A study found that methylation of the BMP3 gene promoter was detected in 64.44% of gastric cancer tissue samples.
·Other cancers include cholangiocarcinoma, breast cancer, pancreatic cancer, and lung adenocarcinoma (LUAD).
General information
Name | BMP3 methylation single gene single segment standard |
Cat. No. | CBPE0229-0235 |
Format | Genomic DNA |
Size | 1ug |
Buffer | Tris-EDTA |
Intended Use | Research Use Only |
Concentration | Download for COA |
Purity | Download for COA |
DNA electrophoresis | Download for COA |
Storage Conditions | 2~8℃ |
Expiry | 36 months from the date of manufacture |
Remark | The data in the instruction manual is the data of a single test, and the specific data of each batch is subject to delivery. |
Technical Data
Classification | Cat No. | Name | Unit Size | Methylation level | |
chr12:25055913-25056108(hg19) | |||||
quality control standard | Positive quality control | CBPE0236 | BCAT1 Methylation Positive control | 1ug | 95.50% |
Negative quality control | CBPE0237 | BCAT1 Methylation Negative control (< Cut off) | 1ug | 0.08% | |
Reference Standard | High positive reference-1 | CBPE0238 | BCAT1 Methylation Reference Standard with > 90% | 1ug | 95.50% |
High positive reference-2 | CBPE0239 | BCAT1 Methylation Reference Standard with 10% | 1ug | 10.79% | |
Low positive reference | CBPE0240 | BCAT1 Methylation Reference Standard with 3% | 1ug | N/A | |
LOD reference | CBPE0241 | BCAT1 Methylation Reference Standard with 1% | 1ug | 1.22% | |
Negative reference | CBPE0242 | BCAT1 Methylation Negative Reference Standard (< Cut off) | 1ug | 0.08% | |
Precision reference | CBPE0240 | BCAT1 Methylation Reference Standard with 3% | 1ug | N/A | |
CBPE0242 | BCAT1 Methylation Negative Reference Standard (< Cut off) | 1ug | 0.08% | ||
Specificity reference | Customization | ||||
Remark | 1. Quality control products are also called accuracy standards, which are used for qualitative judgment; 2. Reference products are used for qualitative and quantitative judgments, among which the judgment of strong positive, weak positive, detection limit, precision, and specificity depends on the specific project. The judgment of this product is only an internal standard; 3. Quality control products are used for performance evaluation, factory inspection, and routine testing and judgment of test kits, and reference products are used for performance evaluation and factory inspection; | ||||
Product Description
The BMP3 (bone morphogenetic protein 3) gene encodes a secreted protein belonging to the TGF-β (transforming growth factor-β) superfamily. Alterations in the methylation status of this gene, particularly hypermethylation of the CpG island in its promoter region, can silence gene expression and is closely associated with the development and progression of various tumors.
Research has found that hypermethylation of the BMP3 gene occurs in:
·Colorectal cancer (CRC): In the majority of CRC cases, the BMP3 gene is hypermethylated and downregulated.
·Gastric cancer: A study found that methylation of the BMP3 gene promoter was detected in 64.44% of gastric cancer tissue samples.
·Other cancers include cholangiocarcinoma, breast cancer, pancreatic cancer, and lung adenocarcinoma (LUAD).
General information
Name | BMP3 methylation single gene single segment standard |
Cat. No. | CBPE0229-0235 |
Format | Genomic DNA |
Size | 1ug |
Buffer | Tris-EDTA |
Intended Use | Research Use Only |
Concentration | Download for COA |
Purity | Download for COA |
DNA electrophoresis | Download for COA |
Storage Conditions | 2~8℃ |
Expiry | 36 months from the date of manufacture |
Remark | The data in the instruction manual is the data of a single test, and the specific data of each batch is subject to delivery. |
Technical Data
Classification | Cat No. | Name | Unit Size | Methylation level | |
chr12:25055913-25056108(hg19) | |||||
quality control standard | Positive quality control | CBPE0236 | BCAT1 Methylation Positive control | 1ug | 95.50% |
Negative quality control | CBPE0237 | BCAT1 Methylation Negative control (< Cut off) | 1ug | 0.08% | |
Reference Standard | High positive reference-1 | CBPE0238 | BCAT1 Methylation Reference Standard with > 90% | 1ug | 95.50% |
High positive reference-2 | CBPE0239 | BCAT1 Methylation Reference Standard with 10% | 1ug | 10.79% | |
Low positive reference | CBPE0240 | BCAT1 Methylation Reference Standard with 3% | 1ug | N/A | |
LOD reference | CBPE0241 | BCAT1 Methylation Reference Standard with 1% | 1ug | 1.22% | |
Negative reference | CBPE0242 | BCAT1 Methylation Negative Reference Standard (< Cut off) | 1ug | 0.08% | |
Precision reference | CBPE0240 | BCAT1 Methylation Reference Standard with 3% | 1ug | N/A | |
CBPE0242 | BCAT1 Methylation Negative Reference Standard (< Cut off) | 1ug | 0.08% | ||
Specificity reference | Customization | ||||
Remark | 1. Quality control products are also called accuracy standards, which are used for qualitative judgment; 2. Reference products are used for qualitative and quantitative judgments, among which the judgment of strong positive, weak positive, detection limit, precision, and specificity depends on the specific project. The judgment of this product is only an internal standard; 3. Quality control products are used for performance evaluation, factory inspection, and routine testing and judgment of test kits, and reference products are used for performance evaluation and factory inspection; | ||||
General information
Name | BMP3 methylation single gene single segment standard |
Cat. No. | CBPE0229-0235 |
Format | Genomic DNA |
Size | 1ug |
Buffer | Tris-EDTA |
Intended Use | Research Use Only |
Concentration | Download for COA |
Purity | Download for COA |
DNA electrophoresis | Download for COA |
Storage Conditions | 2~8℃ |
Expiry | 36 months from the date of manufacture |
Remark | The data in the instruction manual is the data of a single test, and the specific data of each batch is subject to delivery. |
General information
Name | BMP3 methylation single gene single segment standard |
Cat. No. | CBPE0229-0235 |
Format | Genomic DNA |
Size | 1ug |
Buffer | Tris-EDTA |
Intended Use | Research Use Only |
Concentration | Download for COA |
Purity | Download for COA |
DNA electrophoresis | Download for COA |
Storage Conditions | 2~8℃ |
Expiry | 36 months from the date of manufacture |
Remark | The data in the instruction manual is the data of a single test, and the specific data of each batch is subject to delivery. |
Technical Data
Classification | Cat No. | Name | Unit Size | Methylation level | |
chr12:25055913-25056108(hg19) | |||||
quality control standard | Positive quality control | CBPE0236 | BCAT1 Methylation Positive control | 1ug | 95.50% |
Negative quality control | CBPE0237 | BCAT1 Methylation Negative control (< Cut off) | 1ug | 0.08% | |
Reference Standard | High positive reference-1 | CBPE0238 | BCAT1 Methylation Reference Standard with > 90% | 1ug | 95.50% |
High positive reference-2 | CBPE0239 | BCAT1 Methylation Reference Standard with 10% | 1ug | 10.79% | |
Low positive reference | CBPE0240 | BCAT1 Methylation Reference Standard with 3% | 1ug | N/A | |
LOD reference | CBPE0241 | BCAT1 Methylation Reference Standard with 1% | 1ug | 1.22% | |
Negative reference | CBPE0242 | BCAT1 Methylation Negative Reference Standard (< Cut off) | 1ug | 0.08% | |
Precision reference | CBPE0240 | BCAT1 Methylation Reference Standard with 3% | 1ug | N/A | |
CBPE0242 | BCAT1 Methylation Negative Reference Standard (< Cut off) | 1ug | 0.08% | ||
Specificity reference | Customization | ||||
Remark | 1. Quality control products are also called accuracy standards, which are used for qualitative judgment; 2. Reference products are used for qualitative and quantitative judgments, among which the judgment of strong positive, weak positive, detection limit, precision, and specificity depends on the specific project. The judgment of this product is only an internal standard; 3. Quality control products are used for performance evaluation, factory inspection, and routine testing and judgment of test kits, and reference products are used for performance evaluation and factory inspection; | ||||
Technical Data
Classification | Cat No. | Name | Unit Size | Methylation level | |
chr12:25055913-25056108(hg19) | |||||
quality control standard | Positive quality control | CBPE0236 | BCAT1 Methylation Positive control | 1ug | 95.50% |
Negative quality control | CBPE0237 | BCAT1 Methylation Negative control (< Cut off) | 1ug | 0.08% | |
Reference Standard | High positive reference-1 | CBPE0238 | BCAT1 Methylation Reference Standard with > 90% | 1ug | 95.50% |
High positive reference-2 | CBPE0239 | BCAT1 Methylation Reference Standard with 10% | 1ug | 10.79% | |
Low positive reference | CBPE0240 | BCAT1 Methylation Reference Standard with 3% | 1ug | N/A | |
LOD reference | CBPE0241 | BCAT1 Methylation Reference Standard with 1% | 1ug | 1.22% | |
Negative reference | CBPE0242 | BCAT1 Methylation Negative Reference Standard (< Cut off) | 1ug | 0.08% | |
Precision reference | CBPE0240 | BCAT1 Methylation Reference Standard with 3% | 1ug | N/A | |
CBPE0242 | BCAT1 Methylation Negative Reference Standard (< Cut off) | 1ug | 0.08% | ||
Specificity reference | Customization | ||||
Remark | 1. Quality control products are also called accuracy standards, which are used for qualitative judgment; 2. Reference products are used for qualitative and quantitative judgments, among which the judgment of strong positive, weak positive, detection limit, precision, and specificity depends on the specific project. The judgment of this product is only an internal standard; 3. Quality control products are used for performance evaluation, factory inspection, and routine testing and judgment of test kits, and reference products are used for performance evaluation and factory inspection; | ||||
