- Home
- Products
- Services
- Resources
- About Us
- News
- Contact
Description
HLA Single-locus genotyping standard include mainly HLA-B typing, which have been verified by sanger sequencing and the gold standard PCR-SBT method recommended by WHO. Such products are relevant for the personalization of medicines, such as auxiliary diagnosis of ankylosing spondylitis (AS),medication guidance for gout and Stephen Johnson syndrome (SJS) caused by anti-epileptic drug carbamazepine, etc
General information
Product Information | HLA-B*27:04 Reference Standard | HLA-B*27:05 Reference Standard | HLA-B*57:01 Reference Standard | HLA-B*15:02 Reference Standard | HLA-B*58:01 Reference Standard | HLA-B*13:01 Reference Standard | HLA-B*27:07 Reference Standard | HLA-B*58:01 Reference Standard-2 |
Catalog ID | CBPQ0001 | CBPQ0002 | CBPQ0003 | CBPQ0004 | CBPQ0005 | CBPQ0006 | CBPQ0009 | CBPQ0011 |
Format | Genomic DNA | Genomic DNA | Genomic DNA | Genomic DNA | Genomic DNA | Genomic DNA | Genomic DNA | Genomic DNA |
Intended Use | Research Use Only | Research Use Only | Research Use Only | Research Use Only | Research Use Only | Research Use Only | Research Use Only | Research Use Only |
Unit Size | 1ug | 1ug | 1ug | 1ug | 1ug | 1ug | 1ug | 1ug |
Storage | 2-8°C | 2-8°C | 2-8°C | 2-8°C | 2-8°C | 2-8°C | 2-8°C | 2-8°C |
Expiry | 36 months from the date of manufacture | 36 months from the date of manufacture | 36 months from the date of manufacture | 36 months from the date of manufacture | 36 months from the date of manufacture | 36 months from the date of manufacture | 36 months from the date of manufacture | 36 months from the date of manufacture |
Technical Data
Product Information | HLA-B*27:04 Reference Standard | HLA-B*27:05 Reference Standard | HLA-B*57:01 Reference Standard | HLA-B*15:02 Reference Standard | HLA-B*58:01 Reference Standard | HLA-B*13:01 Reference Standard | HLA-B*27:07 Reference Standard | HLA-B*58:01 Reference Standard-2 |
Allele 1 | HLA-B*27:04 | HLA-B*27:05 | HLA-B*57:01 | HLA-B*15:02 | HLA-B*58:01 | HLA-B*13:01 | HLA-B*27:07 | HLA-B*58:01 |
Allele 12 | HLA-B*40:01
| HLA-B*27:05 | HLA-B*57:01 | HLA-B*58:01 | HLA-B*15:02 | HLA-B*13:01 | HLA-B*44:03 | HLA-B*58:02 |
Buffer | Tris-EDTA | Tris-EDTA | Tris-EDTA | Tris-EDTA | Tris-EDTA | Tris-EDTA | Tris-EDTA | Tris-EDTA |
Sanger sequencing | ||||||||
| Verification Method | PCR-SBT/Sanger | PCR-SBT/Sanger | PCR-SBT/Sanger | PCR-SBT/Sanger | PCR-SBT/Sanger | PCR-SBT/Sanger | PCR-SBT/Sanger | PCR-SBT/Sanger |
Product application
HLA (human leukocyte antigen) has a variety of applications in medicine, mainly including the following aspects:
1. Organ transplant matching: HLA compatibility testing is the key to successful organ transplantation. Highly matched HLA can reduce rejection after transplantation, especially hematopoietic stem cell transplantation requires a high degree of matching
2. Disease correlation research: Specific HLA genotypes are associated with the risk of certain diseases. For example, HLA-B27 is associated with ankylosing spondylitis, HLA-DQ2/DQ8 is associated with celiac disease and other diseases
3. Prevention of transfusion reactions: HLA antibodies can cause transfusion reactions, such as ineffective platelet transfusions. Immune responses can be reduced by matching donor and recipient HLA
4. Forensic applications: HLA genotypes are highly polymorphic and are often used for paternity testing and individual identification
5. Drug allergy prediction: Certain HLA alleles are associated with drug allergies, such as HLA-B*57:01 is associated with abacavir allergy. Testing can prevent serious drug reactions
6. New CAR-T cell therapy : HLA is also used in immunotherapy, for example, A2B530 CAR-T cell therapy has been granted orphan drug designation by the FDA for the treatment of certain types of colorectal cancer patients
Description
HLA Single-locus genotyping standard include mainly HLA-B typing, which have been verified by sanger sequencing and the gold standard PCR-SBT method recommended by WHO. Such products are relevant for the personalization of medicines, such as auxiliary diagnosis of ankylosing spondylitis (AS),medication guidance for gout and Stephen Johnson syndrome (SJS) caused by anti-epileptic drug carbamazepine, etc
General information
Product Information | HLA-B*27:04 Reference Standard | HLA-B*27:05 Reference Standard | HLA-B*57:01 Reference Standard | HLA-B*15:02 Reference Standard | HLA-B*58:01 Reference Standard | HLA-B*13:01 Reference Standard | HLA-B*27:07 Reference Standard | HLA-B*58:01 Reference Standard-2 |
Catalog ID | CBPQ0001 | CBPQ0002 | CBPQ0003 | CBPQ0004 | CBPQ0005 | CBPQ0006 | CBPQ0009 | CBPQ0011 |
Format | Genomic DNA | Genomic DNA | Genomic DNA | Genomic DNA | Genomic DNA | Genomic DNA | Genomic DNA | Genomic DNA |
Intended Use | Research Use Only | Research Use Only | Research Use Only | Research Use Only | Research Use Only | Research Use Only | Research Use Only | Research Use Only |
Unit Size | 1ug | 1ug | 1ug | 1ug | 1ug | 1ug | 1ug | 1ug |
Storage | 2-8°C | 2-8°C | 2-8°C | 2-8°C | 2-8°C | 2-8°C | 2-8°C | 2-8°C |
Expiry | 36 months from the date of manufacture | 36 months from the date of manufacture | 36 months from the date of manufacture | 36 months from the date of manufacture | 36 months from the date of manufacture | 36 months from the date of manufacture | 36 months from the date of manufacture | 36 months from the date of manufacture |
Technical Data
Product Information | HLA-B*27:04 Reference Standard | HLA-B*27:05 Reference Standard | HLA-B*57:01 Reference Standard | HLA-B*15:02 Reference Standard | HLA-B*58:01 Reference Standard | HLA-B*13:01 Reference Standard | HLA-B*27:07 Reference Standard | HLA-B*58:01 Reference Standard-2 |
Allele 1 | HLA-B*27:04 | HLA-B*27:05 | HLA-B*57:01 | HLA-B*15:02 | HLA-B*58:01 | HLA-B*13:01 | HLA-B*27:07 | HLA-B*58:01 |
Allele 12 | HLA-B*40:01
| HLA-B*27:05 | HLA-B*57:01 | HLA-B*58:01 | HLA-B*15:02 | HLA-B*13:01 | HLA-B*44:03 | HLA-B*58:02 |
Buffer | Tris-EDTA | Tris-EDTA | Tris-EDTA | Tris-EDTA | Tris-EDTA | Tris-EDTA | Tris-EDTA | Tris-EDTA |
Sanger sequencing | ||||||||
| Verification Method | PCR-SBT/Sanger | PCR-SBT/Sanger | PCR-SBT/Sanger | PCR-SBT/Sanger | PCR-SBT/Sanger | PCR-SBT/Sanger | PCR-SBT/Sanger | PCR-SBT/Sanger |
Product application
HLA (human leukocyte antigen) has a variety of applications in medicine, mainly including the following aspects:
1. Organ transplant matching: HLA compatibility testing is the key to successful organ transplantation. Highly matched HLA can reduce rejection after transplantation, especially hematopoietic stem cell transplantation requires a high degree of matching
2. Disease correlation research: Specific HLA genotypes are associated with the risk of certain diseases. For example, HLA-B27 is associated with ankylosing spondylitis, HLA-DQ2/DQ8 is associated with celiac disease and other diseases
3. Prevention of transfusion reactions: HLA antibodies can cause transfusion reactions, such as ineffective platelet transfusions. Immune responses can be reduced by matching donor and recipient HLA
4. Forensic applications: HLA genotypes are highly polymorphic and are often used for paternity testing and individual identification
5. Drug allergy prediction: Certain HLA alleles are associated with drug allergies, such as HLA-B*57:01 is associated with abacavir allergy. Testing can prevent serious drug reactions
6. New CAR-T cell therapy : HLA is also used in immunotherapy, for example, A2B530 CAR-T cell therapy has been granted orphan drug designation by the FDA for the treatment of certain types of colorectal cancer patients
